Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14982
Title: Synthesis, antimicrobial and antioxidant activities of some indole analogues containing naphthyridine and pyrimidonaphthyridine systems
Authors: Saundane, Anand R
Walmik, Prabhaker
Keywords: Indole
Pyridine
Naphthyridine
Pyrimidonaphthyridine
Antimicrobial activity
Antioxidant activity
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract:   2-Amino-4-(2'-methoxynapthalen-6'-yl)-6-(4-subtituted phenyl)-pyridin-3-carbonitriles <b style="mso-bidi-font-weight:normal">2a-c</b> have been prepared by cyclocondensation of substituted chalcones <b style="mso-bidi-font-weight:normal">1a-c</b> with malanonitrile in the presence of ammonium acetate. The compounds <b style="mso-bidi-font-weight:normal">2a-c</b> on cyclocondensation with (5'-substituted 2'-phenyl-1<i style="mso-bidi-font-style: normal">H</i>-indol-3'-yl)-acrylonitriles <b style="mso-bidi-font-weight:normal">3a-c</b> afford the key intermediates 4-amino-5-(2'-methoxynaphthalen-6'-yl)-7-aryl-2-(5'-substituted 2'-phenyl-1<i style="mso-bidi-font-style:normal">H</i>-indol-3'-yl)-1,8-naphthyridin-5-carbonitriles <b style="mso-bidi-font-weight:normal">4a-i</b>. Compounds <b style="mso-bidi-font-weight: normal">4a-i</b> when subjected to annulations using simple and inexpensive reagents such as formic acid, carbon disulfide and formamide afford title compounds <b style="mso-bidi-font-weight:normal">5a-i</b>, <b style="mso-bidi-font-weight: normal">6a-i</b> and <b style="mso-bidi-font-weight:normal">7a-i</b>, respectively. The structures of all these previously unknown compounds have been established on the basis of spectral and analytical data. All synthesized compounds have been screened for their antimicrobial and antioxidant activities. Compounds <b style="mso-bidi-font-weight:normal">2b</b>, <b style="mso-bidi-font-weight:normal">5d </b>and <b style="mso-bidi-font-weight: normal">6a</b> exhibit maximum zone of inhibition against the microorganisms <i style="mso-bidi-font-style:normal">E. coli</i>, <i style="mso-bidi-font-style: normal">A. flavus</i> and <i style="mso-bidi-font-style:normal">A. terrus</i> whereas compound <b style="mso-bidi-font-weight:normal">7c</b> shows maximum zone of inhibition against microbes <i style="mso-bidi-font-style:normal">E. coli</i>,<i style="mso-bidi-font-style:normal"> S. aureus</i>,<i style="mso-bidi-font-style:normal"> A. oryzae</i> and<i style="mso-bidi-font-style: normal"> A. niger</i>. Compounds <b style="mso-bidi-font-weight:normal">4h</b>, <b style="mso-bidi-font-weight:normal">5g,</b> <b style="mso-bidi-font-weight: normal">5h</b>, <b style="mso-bidi-font-weight:normal">6g</b> and <b style="mso-bidi-font-weight:normal">6h</b> exhibit good radical scavenging activity as compared to the standards.
Description: 1593-1606
URI: http://hdl.handle.net/123456789/14982
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(11) [November 2012]

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