20-Dec-2013
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.11 [2012] >
IJTK Vol.11(4) [October 2012] >
| Title: | Elucidation of mechanism of Anti-arthritic action of Arthosansar- a polyherbal formulation |
| Authors: | Sumanth, Meera
Anusha
Swetha, S |
| Keywords: | Anti-arthritic activity
Immunomodulation
Anti-inflammatory
Analgesic
Neutrophil infiltration |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A01D 9/00, A01D 9/01, A01D 9/04, A01D 9/08, A01D 9/09, A01D 9/10, A01D 9/11, A01D 4/29, A01D 20/54 |
| Abstract: | To elucidate the mechanism of anti-arthritic
action of the Arthosansar, a
polyherbal formulation has proven anti-arthritic activity. The mechanism is
elucidated by emphasizing on immunomodulation, anti-inflammatory and analgesic
action. The study is carried out using CFA induced arthritis in rats, carrageenan
induced peritonitis in mice, inflammation induced by various phlogistic agents
in rats, acetic acid induced writhing in mice and tail-immersion test in mice. Arthosansar significantly (P<0.001)
inhibited proliferation of lymphocytes in CFA induced arthritic rats.
Arthosansar significantly (P<0.001) inhibited neutrophil infiltration in
carrageenan induced peritonitis in mice, inhibited the release of inflammatory
mediators (PGs, histamine, 5-HT and bradykinin) and pain mediated through these
mediators in acetic acid induced writhing test. Arthosansar also showed
significant (P<0.001) increase in latency period in tail immersion test in
mice. Arthosansar exhibits anti-arthritic activity by. (a) Inhibiting
lymphocyte proliferation (b) Inhibiting production of IF- , TNF- , IL-2 (c)
Inhibiting release of inflammatory mediators PGs, histamine, 5-HT and
bradykinin (d) Exhibits antinociceptive action through opioid receptors and by
promoting release of endogenous peptides. |
| Page(s): | 704-713 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.11(4) [October 2012]
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