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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(11) [November 2012] >
| Title: | Virgin coconut oil improves hepatic lipid metabolism in rats–compared with copra oil, olive oil and sunflower oil |
| Authors: | Arunima, S
Rajamohan, T |
| Keywords: | Apolipoproteins
Bile acids
Lipid levels
Lipogenic enzymes
Lipoprotein lipase
Olive oil
Virgin coconut oil |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Effect of virgin coconut oil (VCO) on lipid
levels and regulation of lipid metabolism compared with copra oil (CO), olive
oil (OO), and sunflower oil (SFO) has been reported. Male Sprague-Dawley rats
were fed different oils at 8% level
for 45 days along with synthetic diet. Results showed that VCO feeding
significantly lowered (P<0.05) levels of
total cholesterol, LDL+ VLDL cholesterol, Apo B and triglycerides in serum and
tissues compared to rats fed CO, OO and SFO, while HDL-cholesterol and Apo A1
were significantly (P<0.05) higher in serum of rats fed VCO than
other
groups. Hepatic lipogenesis was also down regulated in VCO fed rats, which was
evident from the decreased activities of enzymes viz., HMG CoA reductase,
glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malic enzyme.
In addition, VCO significantly (P<0.05) increased the activities of
lipoprotein lipase, lecithin cholesterol acyl transferase and enhanced
formation of bile acids. Results demonstrated hypolipidemic effect of VCO by
regulating the synthesis
and degradation of lipids. |
| Page(s): | 802-809 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(11) [November 2012]
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