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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(11) [November 2012] >
| Title: | Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts |
| Authors: | Acharya, S R
Acharya, N S
Bhangale, J O
Shah, S K
Pandya, S S |
| Keywords: | Asparagus racemosus
Antioxidant activity
CCl4, Hepatoprotection |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The antioxidant activities of the crude
hydro-alcoholic extract (CE) and its four fractions viz. methanol (MF), ethyl
acetate (EF), n-Butanol (BF), and precipitated aqueous (PAF) of A.racemosus roots tested decreased in
the order of EF > MF > CE > BF > PAF when investigated by DPPH free
radical scavenging assay. Under iron induced lipid peroxidation almost similar
results were observed except that the activity was more in PAF than BF. Hepatoprotective
activity of the extracts was also demonstrable in vivo by the inhibition of–CCl4 induced formation of
lipid peroxides in the liver of rats by pretreatment with the extracts. CCl4–induced
hepatotoxicity in rats, as judged by the raised serum enzymes viz. glutamate
oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline
phosphatase and total and direct bilirubin as well as oxidant enzyme viz. malon
dialdehyde were prevented, while antioxidant enzymes viz. superoxide dismutase,
reduced glutathione and catalase were elevated by pretreatment with the
extracts, demonstrating the potent hepatoprotective action of the roots of A. racemosus. |
| Page(s): | 795-801 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(11) [November 2012]
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