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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(11) [November 2012] >
| Title: | Antiobesity effect of Safoof Mohazzil, a polyherbal formulation, in cafeteria diet induced obesity in rats |
| Authors: | Gupta, Pooja
Mehla, Jogender
Gupta, Yogendra Kumar |
| Keywords: | Cafeteria diet
Diet induced obesity
Herbal
Insulin
Leptin
Safoof Mohazzil
Unani medicine |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Obesity is reaching epidemic proportions all over the world yet it
lacks adequate treatment. Most of the drugs have failed either due to
ineffectiveness or adverse effects. Complementary and alternative system of
medicine is being used since ancient times. However, many of them have not been
tested for efficacy and safety using modern scientific methods. Therefore, the
antiobesity effect of Safoof Mohazzil, a polyherbal formulation, was evaluated
in cafeteria diet induced obesity in female Sprague
Dawley rats. Animals weighing 100–150 g were divided into four groups (n=8)
i.e. standard pellet diet, cafeteria diet control, cafeteria diet + Safoof
Mohazzil and standard pellet diet plus Safoof Mohazzil. The formulation was
administered orally at a dose of 1 g/kg/day for 14 weeks. At the end of study,
cafeteria diet significantly increased body weight, Lee’s index, lipid profile
(cholesterol and triglycerides), insulin and leptin levels as compared to
standard pellet diet control group. Fourteen week treatment with Safoof
Mohazzil significantly prevented the increase in body weight, Lee’s index,
lipid profile, insulin and leptin levels as compared to cafeteria diet control
group without affecting food and water intake. Safoof Mohazzil had no adverse
effect on hepatic transaminases, locomotor activity and motor coordination. The
study provides evidence for antiobesity effect of Safoof Mohazzil. |
| Page(s): | 776-784 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(11) [November 2012]
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