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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(11) [November 2012] >
| Title: | Chronic fluoxetine treatment affects gene expression of catecholamine enzymes in the heart of depression model rats |
| Authors: | Spasojevic, Natasa
Jovanovic, Predrag
Dronjak, Sladjana |
| Keywords: | Antidepressant
Catecholamine enzymes
Depression
Gene expression
Heart |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Depression is associated with increased risk
of coronary heart diseases. Selective serotonin reuptake inhibitors (SSRIs) have been proved to be very effective in
normalizing symptoms of depression, but the data on possible influence of these drugs
on cardiovascular function is controversial. Applying Taqman RT-PCR
assay, the effect of chronic treatment with a SSRI antidepressant fluoxetine
has been investigated on gene expression of catecholamine biosynthetic enzymes
in all four heart chambers of rats with signs of depression. Depression was
induced by exposing the animals to chronic unpredictable mild stress (CUMS). Tyrosine-hydroxylase (TH)
and dopamine-ß-hydroxylase (DBH) mRNA
levels were decreased both in right and left atria, while phenylethanolamine
N-methyltransferase (PNMT) mRNAs were
increased in left atria and both ventricles of depression model rats.
Fluoxetine elevated gene expression of TH and DBH in atria, but did not
influence this process in the ventricles. Also, this antidepressant did not express a significant effect on the
level of PNMT mRNA both in atria and ventricles. These
results indicate
that fluoxetine acted stimulating noradrenaline synthesis in the heart, which could lead to increased risk of heart disease.
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| Page(s): | 771-775 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(11) [November 2012]
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