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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(11) [November 2012] >
| Title: | Olfactory tract transection reveals robust tissue-level plasticity by cellular numbers and neurotrophic factor expression in olfactory bulb |
| Authors: | Khan, Mansoor Ali BM
Thomas, Sunil
Sinha, Jitendra Kumar
Alladi, Phalguni Anand
Ravi, V
Raju, T R |
| Keywords: | Mitral cells
Neurotrophic factors
Neuroregeneration
Olfactory bulb
Olfactory tract transection
Real-time PCR |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Nervous system
lesions are characterized by the loss of neuronal numbers and types. The
neurotrophic factor levels in an injured tissue reflect their potential for
regeneration. This hypothesis was investigated in olfactory bulb (OB), where olfactory tract was surgically transected
disrupting neuronal migration and turnover. The effects were followed with
quantification of mitral cells and three neurotrophic factors mRNA levels for 6
weeks. The neuronal numbers decreased by 3rd- and 4th-week
in transected OBs followed by their restoration, comparable with that of
controls at 5th- and 6th-week. The endogenous levels of
three neurotrophic factors – (brain derived neurotrophic factor, insulin growth
factor-1 and fibroblast growth factor-2) using qPCR showed increase at 2nd-week
by 136-, 8- and 2-fold respectively. Also, there was a significant increase in
specific neurotrophic factors at 5th-week and 6th-weeks.
The results propose a temporal link between deployment of neurotrophic factors
and the plausible restorative events for mitral cell numbers in OB. |
| Page(s): | 765-770 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(11) [November 2012]
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