|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Pure & Applied Physics (IJPAP) >
IJPAP Vol.50 [2012] >
IJPAP Vol.50(11) [November 2012] >
| Title: | Determination of relative biological effectiveness of 3.2 MeV proton beam from folded tandem ion accelerator |
| Authors: | Joseph, Praveen
Narayana, Y
Bhat, N N
Santra, S
Thomas, R G
Gupta, S K |
| Keywords: | Folded tandem ion accelerator
Proton
Gamma
Human tumor adeno carcinoma
Relative biological effectiveness |
| Issue Date: | Nov-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In the present
study, DNA damage induced by proton beam from Folded Tandem Ion Accelerator
(FOTIA) and gamma radiation from a 60Co source on human tumor adeno
carcinoma (HT 29) cells has been studied. Dosimetry for proton radiation has
been carried out using surface barrier semiconductor detectors and flux was
adjusted to be 1.6 106 with fluence variation
to deliver different doses. Proton beam of intermediate LET (12.5 keV µm-1), which has a penetration of 150 µm
in tissue, was used for the study. Radiation damage induced on cells was
evaluated by comet assay and the comet parameter used was Olive Tail Moment
(OTM). The average RBE was calculated from the proton and gamma dose required
for the iso-effective OTM.
|
| Page(s): | 789-792 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1041 (Online); 0019-5596 (Print) |
| Source: | IJPAP Vol.50(11) [November 2012]
|
|
