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Title: Fluorescence and CD studies of protein denaturation in the presence of sub-picomolar gold nanoparticles
Authors: Ojha, K
Chowdhury, P K
Ganguli, A K
Keywords: Protein-nanoparticle interactions;Protein conformation;Protein denaturation;Thermal denaturation;Chemical denaturation;Nanoparticles;Gold nanoparticles;Fluorescence spectroscopy;Circular dichroism
Issue Date: Nov-2012
Publisher: NISCAIR-CSIR, India
Abstract: The dependence of nanoparticle concentration on the conformation of bovine serum albumin has been studied. A very small but consistent enhancement in the tryptophan emission is observed in the presence of sub-picomolar concentration of gold nanoparticles. At this concentration, the bovine serum albumin unfolding profile in presence and absence of nanoparticles are quite similar and the protein conformation remains essentially conserved.
Page(s): 1561-1566
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.51A(11) [November 2012]

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