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Indian Journal of Geo-Marine Sciences (IJMS) >
IJMS Vol.41 [2012] >
IJMS Vol.41(5) [October 2012] >
| Title: | In-vitro modulation of Na+ K+, Mg++ ATPases and AchE by sea anemone toxic proteins |
| Authors: | Ravindran, Vinoth S
Kannan, L
Venkateshvaran, K |
| Keywords: | Sea anemones
Proteins
Sodium pump
Acetylcholine
Neurotoxins
Enzyme |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The crude as well as partially purified
protein fractions of the sea anemone species viz. Heteractis magnifica,
Stichodactyla haddoni and Paracodylactis sinensis, were collected
from the Gulf of Mannar, southeast coast of India. These were found to modulate
the functioning of the sodium pump (Na+ K+, Mg++
ATPase) at the presynaptic
complex of neuro-transmission, thereby affecting ATP hydrolysis. They promote cholinestrase activity at the post synaptic complex by
modulating the activity of the enzyme Acetyl Choline Esterase (AchE).
Modulation was dose dependent. The proteins were toxic to mice.
Histopathological observations reveal that the toxins affected the anatomy of
the brain. Toxin injected mice showed various behavioral changes including
manner shivering of fore limbs, loss of balance, opaque eyes, convulsions,
paralysis, micturiction, flexing of muscles, prodding (insensitive to
stimulii), dragging of hind limbs, rolling of tail, foaming from mouth and
exophthalmia. This could be possibly correlated with CNS dysfunction.
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| Page(s): | 451-456 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJMS Vol.41(5) [October 2012]
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