NISCAIR Online Periodicals Repository

Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.71 [2012] >
JSIR Vol.71(10) [October 2012] >

Title: Formulation, optimization and evaluation of enteric coated tablets of Para-amino salicylate sodium
Authors: Verma, Anurag
Islam, Shakul
Mishra, Arun K.
Pandit, Jayant K.
Keywords: PAS Sodium
Opadry white
Acryl EZE
Enteric coating
Issue Date: Oct-2012
Publisher: NISCAIR-CSIR, India
Abstract: The objective of present investigation was to develop pharmaceutically elegant, stable, economic and easy to scale up enteric coated tablet formulation for intestinal delivery of highly gastric irritant and high dose drug, PAS sodium. Various capsule shaped tablet formulations were prepared using wet granulation technique. Formulations showing best flow properties were first subcoated with Opadry white, followed by enteric coating with Acryl-EZE aqueous acrylic enteric system (Eudragit L100-55 with pigment, surfactants and plasicizers). The enteric coated tablets of optimized formulation (s) exhibited best coating characteristics (measured in terms of coating uniformity and % coating process efficiency), remained intact for 120 min in 0.1 M HCl (pH 1.2) and released almost entire drug within 45 min in phosphate buffer (pH 6.8). Further, PAS exhibited excellent stability in phosphate buffer during the entire duration of dissolution. TO : T he prepared enteric coated tablets showed excellent physical and chemical stability, when subjected to accelerated stability studies for three months. Further, when compared to marketed formulation (Pasco Acri), the prepared enteric coated tablets showed excellent similarities with marketed product (with respect to disintegration time, drug release) thereby establishing bioequivalence with marketed product.
Page(s): 667-677
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.71(10) [October 2012]

Files in This Item:

File Description SizeFormat
JSIR 71(10) 667-677.pdf256.31 kBAdobe PDFView/Open
 Current Page Visits: 254 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 171695 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: