|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.71 [2012] >
JSIR Vol.71(10) [October 2012] >
| Title: | Formulation, optimization and evaluation of enteric coated tablets of Para-amino salicylate sodium |
| Authors: | Verma, Anurag
Islam, Shakul
Mishra, Arun K.
Pandit, Jayant K. |
| Keywords: | PAS Sodium
Opadry white
Acryl EZE
Enteric coating
Dissolution |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The objective of present investigation was to develop
pharmaceutically elegant, stable, economic and easy to scale up enteric coated
tablet formulation for intestinal delivery of highly gastric irritant and high dose
drug, PAS sodium. Various capsule shaped tablet formulations were prepared
using wet granulation technique. Formulations showing best flow properties were
first subcoated with Opadry white, followed by enteric coating with Acryl-EZE
aqueous acrylic enteric system (Eudragit L100-55 with pigment, surfactants and
plasicizers). The enteric coated tablets of optimized formulation (s) exhibited
best coating characteristics (measured in terms of coating uniformity and %
coating process efficiency), remained intact for 120 min in 0.1 M HCl (pH 1.2)
and released almost entire drug within 45 min in phosphate buffer (pH 6.8).
Further, PAS exhibited excellent stability in phosphate buffer during the
entire duration of dissolution. TO : T he prepared enteric coated tablets
showed excellent physical and
chemical stability, when subjected to accelerated
stability studies for three months. Further, when compared to marketed
formulation (Pasco Acri), the prepared enteric coated tablets showed excellent
similarities with marketed product (with respect to disintegration time, drug
release) thereby establishing bioequivalence with marketed product. |
| Page(s): | 667-677 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.71(10) [October 2012]
|
|
