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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(5) [October 2012] >
| Title: | Effects of micronutrient status on oxidative stress and exocrine pancreatic function in patients with chronic pancreatitis |
| Authors: | Girish, B N
Vaidyanathan, K
Rajesh, G
Balakrishnan, V |
| Keywords: | Copper
Oxidative stress
Pancreatitis
Pancreatic exocrine insufficiency
Trace elements
Zinc
Ascorbic acid
Elastase-1
Antioxidant enzymes |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Micronutrient deficiency and oxidative
stress in relation to pancreatic exocrine insufficiency among chronic
pancreatitis (CP) patients needs closer scrutiny. In this study, we examined
the role of micronutrients (Zn and Cu) on oxidative stress related parameters
and stool elastase-1 in tropical chronic pancreatitis (TCP) and alcoholic
chronic pancreatitis (ACP) patients. We also compared oxidative stress
parameters in CP patients with low and normal pancreatic stool elastase-1,
estimation of which is the best available test for detecting pancreatic
exocrine insufficiency. Ninety-one
(56 male and 35 female) TCP cases, 84 ACP cases and 113 (60 male and 24 female)
healthy controls were studied. Levels of reduced glutathione (GSH), ascorbic
acid and zinc and activities of glutathione peroxidase (GPx), superoxide
dismutase (SOD) reduced significantly, while thiobarbituric acid reactive substance
(TBARS) and copper level increased significantly in erythrocytes of both ACP
and TCP patients in comparison to healthy controls. However, we did not find
differences in these parameters between diabetic and non-diabetic TCP patients
or between diabetic and non-diabetic ACP patients. The study suggested an
association between pancreatic exocrine insufficiency and oxidative parameters,
while zinc deficiency was found to be correlated with SOD and pancreatic
exocrine insufficiency in CP, irrespective of its etiology. |
| Page(s): | 386-391 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(5) [October 2012]
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