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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(5) [October 2012] >
| Title: | Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice |
| Authors: | Mukherjee, Sukhes
Das, Subir Kumar
Vasudevan, D M |
| Keywords: | Cytokines
Ethanol
Grape
Oxidative Stress
Polyphenols
Vitis vinifera L |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Ethanol
metabolism is known to induce overwhelming production of reactive oxygen
species (ROS) and also to cause associated immune dysfunction. Several
interventional agents of plant origin, in particular fruits and vegetables have
been used to counteract these alterations induced by ethanol. In this study, we
investigated the efficacy of dietary feeding of skin and flesh of grapes (Vitis vinifera L.) on the alterations in
immune and vascular functions in mice with liver abnormalities induced by
chronic ethanol consumption. Results revealed that feeding of both grape skin
and flesh (2.5 g/kg body wt/day) effectively attenuated the oxidative stress
and alterations in immune function and angiogenesis induced by chronic ethanol
consumption (1.6 g/kg body wt/day for 12 weeks) in mice. The antioxidant
actions of the grape skin and flesh as observed in this study might be
attributed to the polyphenols present in the grapes. |
| Page(s): | 379-385 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(5) [October 2012]
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