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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(5) [October 2012] >
| Title: | Cardiovascular Protection by Curcumin: Molecular Aspects |
| Authors: | Kapakos, Georgia
Youreva, Viktoria
Srivastava, Ashok K |
| Keywords: | Curcumin
Atherosclerosis
Cardiac hypertrophy
Vascular dysfunction
Signaling pathways
PKB
MAPKs |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Curcumin is
the active component in turmeric — a spice that has been extensively used as a
culinary agent and a home remedy to prevent and treat many diseases in India and other
countries for hundreds of years. However, systematic studies to understand the
molecular basis of disease preventing or therapeutic properties of curcumin
began to appear in the scientific literature only during the last 40 years. As
a result of these studies, substantial evidence has accumulated to suggest
that curcumin can affect signaling pathways linked to cellular growth,
proliferation, survival, inflammation and transcription. In addition, curcumin
has also been shown to exert anti-atherosclerotic, anti-cancer, anti-diabetic,
anti-inflammatory and anti-oxidative properties in animal models of various
diseases and in human subjects. In this article, we highlight the
cardiovascular protective role of curcumin with an emphasis on the molecular basis
of this effect.
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| Page(s): | 306-315 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(5) [October 2012]
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