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Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(2) [April 2008] >
| Title: | Genetic screening in couples experiencing recurrent assisted procreation failure |
| Authors: | Dada, Rima
Kumar, R
Shamsi, M B
Tanwar, M
Pathak, D
Venkatesh, S
Kumar, M
Singh, H
Singh, K
Aron, M
Kumar, R
Singh, G
Sharma, R K
Gupta, N P |
| Keywords: | Chromosomal abnormalities
Yq microdeletion
Assisted reproduction
AZF
Infertility
Assisted Reproduction (ART)
Intracytoplasmic sperm injection (ICSI) |
| Issue Date: | Apr-2008 |
| Publisher: | CSIR |
| Abstract: | Infertility is a major health problem affecting about 10-20% of couples in the reproductive age group. Male factor is
assumed to be responsible in about 50% cases of infertility. The origin of reduced testicular sperm function is unknown in
about 50-70% of cases and for such couples assisted reproduction techniques (ART) are a boon. Male infertility is often due
to poor semen quality and may be associated with genetic defects. ART has revolutionized management of infertility and
intracytoplasmic sperm injection (ICSI) is the ART procedure of choice in 60-80% cases. Despite major technological
advancements and professional expertise in ART, the success rate and carry-home live birth rate of ICSI is low (18-25%).
This study was aimed to understand the genetic etiopathology of recurrent ART failure. For this, 110 couples with 3 or more
failed ART cycles were recruited. A detailed history was taken and only idiopathic ART failure cases were enrolled for this
study. They were subjected to cytogenetic and Yq microdeletion analysis. Genetic abnormalities were detected in 19
couples. Since a large number (18.2%) cases harboured genetic abnormalities, it is important for all couples opting for ART
to undergo a thorough genetic analysis to prevent recurrent emotional, physical and financial stress. |
| Page(s): | 116-120 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(2) [April 2008]
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