NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(2) [April 2008] >

Title: Genetic screening in couples experiencing recurrent assisted procreation failure
Authors: Dada, Rima
Kumar, R
Shamsi, M B
Tanwar, M
Pathak, D
Venkatesh, S
Kumar, M
Singh, H
Singh, K
Aron, M
Kumar, R
Singh, G
Sharma, R K
Gupta, N P
Keywords: Chromosomal abnormalities
Yq microdeletion
Assisted reproduction
Assisted Reproduction (ART)
Intracytoplasmic sperm injection (ICSI)
Issue Date: Apr-2008
Publisher: CSIR
Abstract: Infertility is a major health problem affecting about 10-20% of couples in the reproductive age group. Male factor is assumed to be responsible in about 50% cases of infertility. The origin of reduced testicular sperm function is unknown in about 50-70% of cases and for such couples assisted reproduction techniques (ART) are a boon. Male infertility is often due to poor semen quality and may be associated with genetic defects. ART has revolutionized management of infertility and intracytoplasmic sperm injection (ICSI) is the ART procedure of choice in 60-80% cases. Despite major technological advancements and professional expertise in ART, the success rate and carry-home live birth rate of ICSI is low (18-25%). This study was aimed to understand the genetic etiopathology of recurrent ART failure. For this, 110 couples with 3 or more failed ART cycles were recruited. A detailed history was taken and only idiopathic ART failure cases were enrolled for this study. They were subjected to cytogenetic and Yq microdeletion analysis. Genetic abnormalities were detected in 19 couples. Since a large number (18.2%) cases harboured genetic abnormalities, it is important for all couples opting for ART to undergo a thorough genetic analysis to prevent recurrent emotional, physical and financial stress.
Page(s): 116-120
ISSN: 0301-1208
Source:IJBB Vol.45(2) [April 2008]

Files in This Item:

File Description SizeFormat
IJBB 45(2) 116-120.pdf48.98 kBAdobe PDFView/Open
 Current Page Visits: 103 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 162255 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: