NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)]
IJNPR Vol.3 [2012] >
IJNPR Vol.3(3) [September 2012] >

Title: Immuno-modulatory activity of Triguna Makaradhwaja - An Ayurvedic compound formulation
Authors: Dhundi, Shraddha N
Ashok, B K
Ravishankar, B
Patgiri, B J
Prajapati, P K
Keywords: Cell mediated immunity
Guduchi Ghana
Triguna Makaradhwaja
Issue Date: Sep-2012
Publisher: NISCAIR-CSIR, India
IPC CodeInt. cl. (2011.01) - A61K 36/00, A61P 37/02
Abstract: The present study was carried out to evaluate immuno-modulatory activity of Triguna Makaradhwaja for humoral antibody formation and cell mediated immunity in established experimental models. Study was carried out in Wistar strain albino rats of either sex and test drug was administered orally at a dose of 3.15 mg/kg along with Guduchi Ghana and honey as adjuvant. Effect of test formulation on anti-body formation against sheep red blood cells was assessed for humoral antibody formation. The test drug and vehicles were administered for 10 consecutive days. On third day, 20% SRBC (Sheep Red Blood Cells) as sensitizing agent was injected subcutaneously to the rats of second, third and fourth groups in the dose of 0.5ml/100 g of body weight. Animals were sacrificed on 11th day. Parameters like haemagglutination titre; haematological, serum biochemical and histology of spleen, thymus and lymph nodes were studied to assess the effect on for humoral immunity. Immunological paw oedema was assessed for cell mediated immunity. Animals were sensitized with triple antigen subcutaneously on first day and the drug administration was continued for seven days. On 7th day animals were challenged with the same antigen by injecting to left hind paw and volume of immunological oedema thus produced was measured by volume displacement method after 24 and 48 hours. Triguna Makaradhwaja apparently enhanced antibody formation and cellularity of immunological organs, while it failed to show any significant impact on immunologically induced paw oedema. This study shows that Triguna Makaradhwaja is having marked immunostimulant effect and weak effect on cell mediated immunity (CMI). The adjuvant Guduchi Ghana and honey per se has immune-potentiating activity and it seems to be added to the therapeutic activity of the main drug.
Page(s): 320-327
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Source:IJNPR Vol.3(3) [September 2012]

Files in This Item:

File Description SizeFormat
IJNPR 3(3) 320-327.pdf339.79 kBAdobe PDFView/Open
 Current Page Visits: 112 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 172329 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: