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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.3 [2012] >
IJNPR Vol.3(3) [September 2012] >
| Title: | Immuno-modulatory activity of Triguna Makaradhwaja - An Ayurvedic compound formulation |
| Authors: | Dhundi, Shraddha N
Ashok, B K
Ravishankar, B
Patgiri, B J
Prajapati, P K |
| Keywords: | Cell mediated immunity
Guduchi Ghana
Haemagglutination
Honey
Triguna Makaradhwaja |
| Issue Date: | Sep-2012 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2011.01) - A61K 36/00, A61P 37/02 |
| Abstract: | The present study was carried out to evaluate
immuno-modulatory activity of Triguna
Makaradhwaja for humoral antibody formation and cell mediated immunity in
established experimental models. Study was carried out in Wistar strain albino
rats of either sex and test drug was administered orally at a dose of 3.15 mg/kg
along with Guduchi Ghana and honey as
adjuvant. Effect of test formulation on anti-body formation against sheep red
blood cells was assessed for humoral antibody formation. The test drug and
vehicles were administered for 10 consecutive days. On third day, 20% SRBC
(Sheep Red Blood Cells) as sensitizing agent was injected subcutaneously to the
rats of second, third and fourth groups in the dose of 0.5ml/100 g of body
weight. Animals were sacrificed on 11th day. Parameters like
haemagglutination titre; haematological, serum biochemical and histology of
spleen, thymus and lymph nodes were studied to assess the effect on for humoral
immunity. Immunological paw oedema was assessed for cell mediated immunity. Animals were
sensitized with triple antigen subcutaneously on first day
and the drug administration was continued for seven
days. On 7th day animals were challenged with the same antigen by
injecting to left hind paw and volume of immunological oedema thus produced was
measured by volume displacement method after 24 and 48 hours. Triguna Makaradhwaja apparently enhanced
antibody formation and cellularity of immunological organs, while it failed to
show any significant impact on immunologically induced paw oedema. This study
shows that Triguna Makaradhwaja is having marked immunostimulant effect and weak effect on cell mediated immunity (CMI). The adjuvant Guduchi Ghana
and honey per se has immune-potentiating activity and it seems to be added to the therapeutic activity of the main
drug.
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| Page(s): | 320-327 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.3(3) [September 2012]
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