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Title: Synthesis and biological screening of 1-N-{4′-[4′′, 4′′′-difluoro diphenyl)-methyl]-piperazine-1′-yl}-4-arylidene-2-penyl-5-oxo-imidazolines
Authors: Savaliya, M D
Dobaria, J G
Bhuva, V V
Purohit, H D
Purohit, D M
Keywords: 5-Oxo-imidazolines
Heterocyclic chemistry
Issue Date: Oct-2012
Publisher: NISCAIR-CSIR, India
Abstract: 1-N[(4′-[4′′,4′′-Difluorodiphenyl)-methyl]-piperazine-1′-yl}-4-aryli­dene-2-phenyl-5-oxo-imidazolines 3a-j have been synthe­sized by the condensation of 1-amino-4-[(4′, 4′′–difluoro­diphenyl)-methyl]-piperazine with different oxazolones. The products have been assayed for their antimicrobial screening against Gram +ve and Gram –ve bacteria, and fungi. Some of the products show moderate activity compared with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and greseofulvin at the same concentration 50 µg/mL. The structures of the products have been elucidated by IR, 1H NMR, mass spectral data and elemental analysis.
Description: 1517-1520
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(10) [October 2012]

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