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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(10) [October 2012] >
| Title: | Synthesis and biological screening of 1-N-{4′-[4′′, 4′′′-difluoro diphenyl)-methyl]-piperazine-1′-yl}-4-arylidene-2-penyl-5-oxo-imidazolines |
| Authors: | Savaliya, M D
Dobaria, J G
Bhuva, V V
Purohit, H D
Purohit, D M |
| Keywords: | 5-Oxo-imidazolines
Heterocyclic chemistry |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 1-N[(4′-[4′′,4′′-Difluorodiphenyl)-methyl]-piperazine-1′-yl}-4-arylidene-2-phenyl-5-oxo-imidazolines
3a-j have been synthesized by the
condensation of 1-amino-4-[(4′, 4′′–difluorodiphenyl)-methyl]-piperazine with
different oxazolones. The products have been assayed for their antimicrobial
screening against Gram +ve and Gram –ve bacteria, and fungi. Some of the
products show moderate activity compared with known standard drugs viz. ampicillin, chloramphenicol,
norfloxacin and greseofulvin at the same concentration 50 µg/mL. The
structures of the products have been elucidated by IR, 1H NMR,
mass spectral data and elemental analysis. |
| Page(s): | 1517-1520 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(10) [October 2012]
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