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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(10) [October 2012] >
| Title: | A green synthesis and antibacterial activity of 2-aryl-5-(coumarin-3-yl)-thiazolo [3,2-b][1,2,4]triazoles |
| Authors: | Jakhar, Komal
Makrandi, J K |
| Keywords: | 3-Aryl-5-mercapto-1,2,4-triazoles
3-acetylcoumarins
Thiazolo[3,2-b][1,2,4]triazoles
Grinding technique
Antibacterial property |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3-Aryl-5-(coumarin-3-yl)acylthio-1,2,4-triazoles
1a-h have been prepared by direct
condensation of 3-acetylcoumarins and various 3-aryl-5-mercapto-1,2,4-triazoles
in the presence of molecular iodine using grinding technique at room
temperature. 3-Aryl-5-(coumarin-3-yl)acylthio-1,2,4-triazoles on cyclisation
with polyphosphoric acid using microwave irradiations under solvent free
conditions give 2-aryl-5-(coumarin-3-yl)-thiazolo[3,2-b][1,2,4]triazoles 2a-h.
The present method is quite environmentally benign as it avoids the use of
hazardous organic solvents during the reaction as well as at working up stage.
Several new compounds have been synthesized and their antibacterial properties
have been described. |
| Page(s): | 1511-1516 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(10) [October 2012]
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