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Title: Synthesis and antimicrobial screening of 4H -2-acetyl-3-amino- furo [3,2-c] benzopyran 4-one, oxime of 4H-2-acetyl-3-amino-furo [3,2-c] benzopyran 4-one, 11H-2-chloromethyl-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzo­pyran-11-one-3N-oxide and 11H-2-[methyl­ene morpholine]-4-methyl-pyrimido­[3,2-d]­furo[3,2-c]benzopyran-11-one-3N-oxide.
Authors: Mulwad, V V
Hegde, A S
Keywords: Chloroacetone
Chloroacetyl chloride
Antimicrobial activity
Issue Date: Oct-2012
Publisher: NISCAIR-CSIR, India
Abstract: A mixture of 2H-3-cyano-4-hydroxy benzopyran 2-one 4a-d, anhydrous potassium carbonate and chloroacetone has been refluxed in dry acetone to give 4H-2-acetyl-3-amino furo [3,2-c] benzopyran 4-one 5a-d. A solution of 5a-d, hydroxylamine hydrochloride in ethanol followed by aqueous potassium hydroxide has been heated to get oxime of 4H-2-acetyl-3-amino-furo [3,2-c] benzopyran 4-one 6a-d. 6a-d which is treated with chloroacetyl chloride in acetone and triethyl amine gives 11H-2-chloromethyl-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide 7a-d. 7a-d has been further treated with ethanolic solution of morpholine to give 11H-2-[methylene morpholine]-4-methyl-pyrimido[3,2-d]furo[3,2-c]benzopyran-11-one-3N-oxide 8a-d. The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have been screened for their antifungal and antibacterial activity and have been found to exhibit good activity.
Page(s): 1504-1510
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(10) [October 2012]

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