Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14807
Title: Synthesis and antimicrobial screening of 4<i style="mso-bidi-font-style:normal">H -</i>2-acetyl-3-amino- furo [3,2-<i>c</i>] benzopyran 4-one, oxime of 4<i style="mso-bidi-font-style:normal">H</i>-2-acetyl-3-amino-furo [3,2-<i>c</i>] benzopyran 4-one, 11<i style="mso-bidi-font-style:normal">H</i>-2-chloromethyl-4-methyl-pyrimido[3,2-<i><span style="mso-bidi-font-weight:bold">d</span></i>]furo[3,2-<i>c</i>]benzo­pyran-11-one-3N-oxide and 11<i style="mso-bidi-font-style:normal">H</i>-2-[methyl­ene morpholine]-4-methyl-pyrimido­[3,2-<i style="mso-bidi-font-style:normal">d</i>]­furo[3,2-<i>c</i>]benzopyran-11-one-3N-oxide.
Authors: Mulwad, V V
Hegde, A S
Keywords: Chloroacetone
Chloroacetyl chloride
Morpholine
Herbicidal
Antimicrobial activity
Issue Date: Oct-2012
Publisher: NISCAIR-CSIR, India
Abstract: A mixture of 2<i style="mso-bidi-font-style:normal">H</i>-3-cyano-4-hydroxy benzopyran 2-one <b style="mso-bidi-font-weight:normal">4a-d</b>,<b style="mso-bidi-font-weight: normal"> </b>anhydrous potassium carbonate and chloroacetone has been refluxed in dry acetone to give<b style="mso-bidi-font-weight:normal"> </b>4<i style="mso-bidi-font-style:normal">H</i>-2-acetyl-3-amino furo [3,2-<i>c</i>] benzopyran 4-one <b style="mso-bidi-font-weight:normal">5a-d</b>. A solution of <b style="mso-bidi-font-weight:normal">5a-d</b>, hydroxylamine hydrochloride in ethanol followed by aqueous potassium hydroxide has been heated to get oxime of 4<i style="mso-bidi-font-style:normal">H</i>-2-acetyl-3-amino-furo [3,2-<i>c</i>] benzopyran 4-one <b style="mso-bidi-font-weight:normal">6a-d</b>. <b style="mso-bidi-font-weight:normal">6a-d</b> which is treated with chloroacetyl chloride in acetone and triethyl amine gives 11<i style="mso-bidi-font-style: normal">H</i>-2-chloromethyl-4-methyl-pyrimido[3,2-<i><span style="mso-bidi-font-weight: bold">d</span></i>]furo[3,2-<i>c</i>]benzopyran-11-one-3N-oxide <b style="mso-bidi-font-weight:normal">7a-d</b>. <b style="mso-bidi-font-weight: normal">7a-d </b>has been further treated with ethanolic solution of morpholine to give 11<i style="mso-bidi-font-style:normal">H</i>-2-[methylene morpholine]-4-methyl-pyrimido[3,2-<i style="mso-bidi-font-style:normal">d</i>]furo[3,2-<i>c</i>]benzopyran-11-one-3N-oxide<b style="mso-bidi-font-weight:normal"> 8a-d</b>.<b style="mso-bidi-font-weight: normal"> </b>The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have been screened for their antifungal and antibacterial activity and have been found to exhibit good activity.
Description: 1504-1510
URI: http://hdl.handle.net/123456789/14807
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(10) [October 2012]

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