Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14802
Title: Synthesis, reactions and anthelmintic activity of 1-[benzimidazol-2-yl]-4-formyl-3-[2′ (-substituted phenyl) indole-3-yl] pyrazoles
Authors: Sharma, Kanti
Jain, Renuka
Keywords: 3-Acetylindolbenzimidazol-2-yl hydrazones
1-[benzimidazol-2-yl]-4-formyl-3[(2′-substituted phenyl) indol-3-yl] pyrazoles
1-[benzimidazol-2-yl] 3-[(2′-substituted phenyl) indol-3-yl]-4-[1′-substituted phenyl prop-2′-ene-1′-ones]-yl pyrazoles
1-[benzimidazol-2-yl]-3-[2′-(substituted phenyl) indol-3-yl]-4-[N-methylene anilines]-yl pyrazoles
Ionic liquid
Anthelmintic activity
Issue Date: Oct-2012
Publisher: NISCAIR-CSIR, India
Abstract: 3-Acetyindolbenzimidazol-2-yl hydrazones <b style="mso-bidi-font-weight:normal">3</b>, which in turn are prepared by the reaction of 2-hydrazinobenzimidazoles <b>1</b> and 3-acetylindoles <b>2</b> in ionic liquid [bmim]PF<sub>6</sub> upon treatment with Vilsmeier Haack reagent undergo cyclization to give the 1-[benzimidazol-2-yl]-4-formyl-3-[(2′-substituted phenyl)indol-3-yl] pyrazoles <b>4</b>, which on further treatment with substituted acetophenones and substituted anilines in ionic liquid [bmim]PF<sub>6 </sub>/ethanol-NaOH/ethanol-AcOH afford the corresponding 1-[benzimidazol-2-yl] 3-[(2′-subsituted phenyl) indol-3-yl]-4-[1′-substituted phenyl prop-2′-ene-1′-ones]-yl pyrazoles <b style="mso-bidi-font-weight:normal">5</b> and 1-[benzimidazol-2-yl]-3-[2′-(substituted phenyl) indol-3-yl]-4-[N-methylene anilines]-yl pyrazoles <b>6</b>. The synthesized compounds have been characterized by analytical and spectral (IR, <sup>1</sup>H and <sup>13</sup>C NMR and FAB mass) data and found to display promising activity when screened for anthelmintic activity against <i>Pheritima posthuma</i>.
Description: 1462-1469
URI: http://hdl.handle.net/123456789/14802
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(10) [October 2012]

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