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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(10) [October 2012] >
| Title: | Synthesis, reactions and anthelmintic activity of 1-[benzimidazol-2-yl]-4-formyl-3-[2′ (-substituted phenyl) indole-3-yl] pyrazoles |
| Authors: | Sharma, Kanti
Jain, Renuka |
| Keywords: | 3-Acetylindolbenzimidazol-2-yl hydrazones
1-[benzimidazol-2-yl]-4-formyl-3[(2′-substituted phenyl) indol-3-yl] pyrazoles
1-[benzimidazol-2-yl] 3-[(2′-substituted phenyl) indol-3-yl]-4-[1′-substituted phenyl prop-2′-ene-1′-ones]-yl pyrazoles
1-[benzimidazol-2-yl]-3-[2′-(substituted phenyl) indol-3-yl]-4-[N-methylene anilines]-yl pyrazoles
Ionic liquid
Anthelmintic activity |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3-Acetyindolbenzimidazol-2-yl hydrazones 3, which in turn are prepared by the
reaction of 2-hydrazinobenzimidazoles 1 and 3-acetylindoles 2 in
ionic liquid [bmim]PF6 upon treatment with Vilsmeier Haack reagent
undergo cyclization to give the 1-[benzimidazol-2-yl]-4-formyl-3-[(2′-substituted
phenyl)indol-3-yl] pyrazoles 4, which on further treatment with
substituted acetophenones and substituted anilines in ionic liquid [bmim]PF6
/ethanol-NaOH/ethanol-AcOH afford the corresponding 1-[benzimidazol-2-yl]
3-[(2′-subsituted phenyl) indol-3-yl]-4-[1′-substituted phenyl
prop-2′-ene-1′-ones]-yl pyrazoles 5
and 1-[benzimidazol-2-yl]-3-[2′-(substituted phenyl) indol-3-yl]-4-[N-methylene
anilines]-yl pyrazoles 6. The synthesized compounds have been
characterized by analytical and spectral (IR, 1H and 13C
NMR and FAB mass) data and found to display promising activity when screened
for anthelmintic activity against Pheritima posthuma. |
| Page(s): | 1462-1469 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(10) [October 2012]
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