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Title: Synthesis, reactions and anthelmintic activity of 1-[benzimidazol-2-yl]-4-formyl-3-[2′ (-substituted phenyl) indole-3-yl] pyrazoles
Authors: Sharma, Kanti
Jain, Renuka
Keywords: 3-Acetylindolbenzimidazol-2-yl hydrazones;1-[benzimidazol-2-yl]-4-formyl-3[(2′-substituted phenyl) indol-3-yl] pyrazoles;1-[benzimidazol-2-yl] 3-[(2′-substituted phenyl) indol-3-yl]-4-[1′-substituted phenyl prop-2′-ene-1′-ones]-yl pyrazoles;1-[benzimidazol-2-yl]-3-[2′-(substituted phenyl) indol-3-yl]-4-[N-methylene anilines]-yl pyrazoles;Ionic liquid;Anthelmintic activity
Issue Date: Oct-2012
Publisher: NISCAIR-CSIR, India
Abstract: 3-Acetyindolbenzimidazol-2-yl hydrazones 3, which in turn are prepared by the reaction of 2-hydrazinobenzimidazoles 1 and 3-acetylindoles 2 in ionic liquid [bmim]PF6 upon treatment with Vilsmeier Haack reagent undergo cyclization to give the 1-[benzimidazol-2-yl]-4-formyl-3-[(2′-substituted phenyl)indol-3-yl] pyrazoles 4, which on further treatment with substituted acetophenones and substituted anilines in ionic liquid [bmim]PF6 /ethanol-NaOH/ethanol-AcOH afford the corresponding 1-[benzimidazol-2-yl] 3-[(2′-subsituted phenyl) indol-3-yl]-4-[1′-substituted phenyl prop-2′-ene-1′-ones]-yl pyrazoles 5 and 1-[benzimidazol-2-yl]-3-[2′-(substituted phenyl) indol-3-yl]-4-[N-methylene anilines]-yl pyrazoles 6. The synthesized compounds have been characterized by analytical and spectral (IR, 1H and 13C NMR and FAB mass) data and found to display promising activity when screened for anthelmintic activity against Pheritima posthuma.
Page(s): 1462-1469
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(10) [October 2012]

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