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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(10) [October 2012] >
| Title: | Abortifacient activity of Plumeria rubra (Linn) pod extract in female albino rats |
| Authors: | Dabhadkar, Dinesh
Zade, Varsha |
| Keywords: | Abortifacient
Female albino rat
Post implantation
Plumeria rubra
Resorption |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | To evaluate the potential abortifacient activity of the aqueous,
alcohol, ethyl acetate and chloroform extracts of P. rubra pod in female albino rats 50, 100 and 200 mg/kg body weight doses of each extract were administered
from day 11 to 15 of pregnancy and animals were allowed to go full term.
The phytochemical screening revealed
the presence of alkaloids, flavonoids, simple phenolics, steroids, tannins and
saponins. Clinical toxicity symptoms such as respiratory distress, salivation,
weight loss, dull eyes, diarrhea, and change in the appearance of fur as well
as mortality were not observed in the animals at any period of the experiment. All
the four extracts of P. rubra pods
exhibited abortifacient activity (8-100%). The extracts significantly reduced
the number of live fetuses, whereas the resorption index and post implantation
losses increased significantly. The % of abortion was found to be highest
(100%) with 200 mg/kg dose of alcoholic extract of P. rubra pods.
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| Page(s): | 702-707 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(10) [October 2012]
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