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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(10) [October 2012] >
| Title: | Effects of perinatal exposure of lithium on neuro-behaviour of developing mice offspring |
| Authors: | Abu-Taweel, Gasem M |
| Keywords: | Behaviour
Esterases
Lithium
Locomotor activity test
Mice offspring
Perinatal exposure
Sensory motor reflexes |
| Issue Date: | Oct-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Lithium (Li) was given to female
Swiss-Webster strain mice at the doses of 15 and 30 mg/kg body weight in their
drinking water. Treatment started from the first day of pregnancy until the
postnatal day fifteen of delivery. Thereafter, the dams were switched to plain
tap water. All offspring were subjected to various tests. The rate of body
weight gain was relatively slower in Li exposed pups. Furthermore, the opening
of eyes and appearance of body hairs in Li exposed pups were also slower as
compared to the controls. The sensory motor reflexes in Li exposed pups were
found to be affected in a dose-dependent manner. Significant relative changes
were also noticed in the levels of acid and alkaline phosphatases in the liver,
and acetylcholinesterase in the brain tissues of the Li exposed developing
offspring in a dose-dependent manner. ‘Locomotor Activity Test’ was performed
in the male offspring only which showed a significant suppressive effect on
most of the elements of this test due to Li exposure. The present Li effects in
the offspring are possibly via in utero action and/or via mother’s milk.
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| Page(s): | 696-701 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(10) [October 2012]
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