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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.45 [2008] >
IJBB Vol.45(2) [April 2008] >
| Title: | Cathepsins: Fundamental Effectors of Endolysosomal Proteolysis |
| Authors: | Guha, Sonia
Padh, Harish |
| Keywords: | Endosome
Cathepsins
Intracellular proteolysis |
| Issue Date: | Apr-2008 |
| Publisher: | CSIR |
| Abstract: | Intracellular protein degradation is a universal feature of eukaryotic cells and vital for nutrition, protein turnover,
intracellular signaling, development and other major physiological processes like antigen presentation and immunity. One of
the major compartments of intracellular proteolysis is the endosome-lysosome system. The latter offers a highly
orchestrated, vesicular pathway for protein transport and ultimate degradation in lysosomes. Though lysosomes are the
classical organelles of complex, multi-enzymatic degradation, it is increasingly evident that endosomes conduct much more
than mere transport functions. Endosomes contain significant levels of proteases like cathepsins and are sites of potent
intracellular proteolysis. Further, discrete classes of endosomes harbor specific cathepsins and perform selective and
exclusive functions. Hence, extra-lysosomal proteolytic machinery within the endocytic pathway enjoys spatial and
temporal control over proteolytic functions. The review outlines the structural association and function(s) of major
endolysosomal cathepsins. |
| Page(s): | 75-90 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.45(2) [April 2008]
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