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Title: Synthesis and cytotoxicity of new quinoline derivatives
Authors: Meshram, H M
Reddy, B Chennakesava
Kumar, D Aravind
Kalyan, M
Ramesh, P
Kavitha, P
Rao, J Venkateswara
Keywords: Quinolines;Suzuki protocol;Anticancer activity
Issue Date: Sep-2012
Publisher: NISCAIR-CSIR, India
Abstract: New 2,8-bis(trifluoromethyl)-4-substituted quinolines have been synthesized from 4-haloquinoline following the Suzuki protocol and N-arylation. The cytotoxicity of the synthesized compounds has been evaluated against human cancer cell lines, and among them, compounds 5a and 5g are found to be the more potent antiproliferative agents.
Page(s): 1411-1416
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(09) [September 2012]

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