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Title: Synthesis and cytotoxicity of new quinoline derivatives
Authors: Meshram, H M
Reddy, B Chennakesava
Kumar, D Aravind
Kalyan, M
Ramesh, P
Kavitha, P
Rao, J Venkateswara
Keywords: Quinolines
Suzuki protocol
Anticancer activity
Issue Date: Sep-2012
Publisher: NISCAIR-CSIR, India
Abstract: New 2,8-bis(trifluoromethyl)-4-substituted quinolines have been synthesized from 4-haloquinoline following the Suzuki protocol and N-arylation. The cytotoxicity of the synthesized compounds has been evaluated against human cancer cell lines, and among them, compounds <b style="mso-bidi-font-weight:normal">5a</b> and <b style="mso-bidi-font-weight:normal">5g</b> are found to be the more potent antiproliferative agents.
Description: 1411-1416
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(09) [September 2012]

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