Please use this identifier to cite or link to this item:
|Title:||PEG-600 mediated one-pot synthesis of quinolinylidinethiazolidine-2,4-diones as potential anti-hyperglycemic agents|
Dubey, P K
|Abstract:||Knoevenagel condensation between quinoline-2-aldehyde 1 and active methylene group containing 2,4-thiazolidinedione (TZD) 2 in PEG-600 at 100°C for 2 hr, without the usage of any base, yields 5-quinolin-2-ylmethylene-thiazolidine-2,4-dione 3 which on alkylation gives N-substituted-5-quinolin-2-ylmethylene-thiazolidine-2,4-diones 5. Alternatively, 5 can also be synthesized by condensing N-substituted-thiazolidine-2,4-dione 4 with 1 in PEG-600 at 100°C. It is possible to prepare 5 directly by condensing 2 with 1 followed by alkylation under one-pot conditions. The α,β-unsaturated carbonyl derivatives 5, thus obtained, are subjected to C=C reduction using magnesium turnings in refluxing ethanol to obtain the corresponding reduced products 6 in high yields which are novel potential anti-hyperglycemic agents.|
|Appears in Collections:||IJC-B Vol.51B(09) [September 2012]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.