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IJC-B Vol.51B [2012] >
IJC-B Vol.51B(09) [September 2012] >


Title: Synthesis of novel 5-substituted isoxazole-3-carboxamide derivatives and cytotoxicity studies on lung cancer cell line
Authors: Veeraswamy, B
Kurumurthy, C
Kumar, G Santhosh
Rao, P Sambasiva
Thelakkat, Kavya
Kotamraju, Srigiridhar
Narsaiah, B
Keywords: Isoxazoles
Benzyloxyaniline
Dicyclohexylcarbodimide
N-hydroxybenzotriazole
Coupling reaction
Issue Date: Sep-2012
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel 5-substituted isoxazole-3-carboxamide derivatives 6 have been prepared by coupling of 5-substituted isoxazole-3-carboxylic acids 3 with substituted-3-benzyloxyaniline 5 using DCC/HOBT as coupling agent. The products 6 have been evaluated for cytotoxicity on A549 lung cancer cell line and compounds 6a, 6b, 6e, 6j are found to show moderate proliferative activity and low cytotoxicity.
Page(s): 1369-1375
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(09) [September 2012]

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