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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(09) [September 2012] >
| Title: | Thirteen-week oral toxicity study of carotenoid pigment from Rhodotorula glutinis DFR-PDY in rats |
| Authors: | Latha, B V
Jeevaratanm, K |
| Keywords: | Antioxidant property
Carotenoids
Microbial pigments
Natural food colourants
Rhotorula glutinis
Toxicity |
| Issue Date: | Sep-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Carotenoids from some of the coloured yeasts like Rhodotorula, Phaffia rhodozyma have attracted commercial interest
as a natural pigment for foods. Red yeast isolated from contaminated Potato
dextrose agar plate (PDA), designated as Rhodotorula
glutinis DFR-PDY has been found to produce carotenoids. In the present
study toxicological evaluation of carotenoid pigment has been reported.
Experiment was conducted on 3 groups of albino rats. One group with vehicle
control (palm oil) and 2 groups with two different doses of red yeast pigment
(lower and higher dose) were fed to rats (both male and female) by gavages for
13 weeks. Gain in body weight of rats and food consumption were monitored at
regular intervals. Hematological studies revealed that there is no much
difference in erythrocytes, packed cell volume, Mean corpuscular volume (MCV),
Mean corpuscular haemoglobin concentration (MCHC), platelets and differential
counts. Total leucocyte count (TLC) is less in case of higher dose group than
the lower and control groups. Whereas, hemoglobin is more in case of higher
dose than the lower dose group and least in control group. Even clinico-chemical
parameters and urine analysis of vehicle control group and pigment fed rats
revealed that there were no major differences between them as well as between
two different genders of rats and also interaction between different doses and
the genders. Histopathology of these experimental animals revealed that there
are no major histological changes found between the groups. It may be concluded
that the whole pigment extract from R.
glutinis DFR-PDY may be used safely in food preparations as food colourant
with an added benefit of antioxidant activity .
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| Page(s): | 645-651 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(09) [September 2012]
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