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IJEB Vol.50(09) [September 2012] >


Title: Protective effects of subchronic caffeine administration on cisplatin induced urogenital toxicity in male mice
Authors: Khazaei, M
Bayat, P D
Ghanbari, A
Khazaei, S
Feizian, M
Khodaei, A
Alian, H A S
Keywords: Apoptosis
Caffeine
Cisplatin
Mice
TUNEL
Issue Date: Sep-2012
Publisher: NISCAIR-CSIR, India
Abstract: In Cisplatin treated group, the degeneration intensity of the kidneys the diameter of seminiferous tubules as well as the apoptotic index in testes and kidney  were increased. In Caffeine+Cisplatin treated groups, the total body weight, the weight of testes and kidneys and also the histopathological data did not show significant differences. The motility of sperm in cisplatin group reduced but in Caffeine+Cisplatin groups this parameter was increased. These data suggest that caffeine recovers toxicity induced by cisplatin in both kidneys and testes of mice.
Page(s): 638-644
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.50(09) [September 2012]

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