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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(09) [September 2012] >
| Title: | Role of C-fibers during acute and chronic stress on formalin-induced paw edema in rats |
| Authors: | Sepehri, Zahra
Fereidoni, Masoud
Niazmand, Saeed |
| Keywords: | Capsaicin
C-fiber
Dexamethasone
Inflammation
Stress |
| Issue Date: | Sep-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Stimulation of peripheral nociceptors leads
to releasing of some mediators such as substance P (SP) and Calcitonin
gene-related peptide (CGRP) and contributes to the edema formation by
vasodilatation induction. On the other hand glucocorticoids have anti-inflammatory
action, and they are elevated in the plasma during stress. This communication
reports C-fibers inflammatory role and the effects of chronic and acute stress
and/or dexamethasone (as stress mimicry) on paw edema induced by formalin at
presence/deficit C-fibers rats. Acute stress and dexamethasone and chronic
dexamethasone have shown an anti-inflammatory effect in C-normal groups, but
chronic stress had no effect on inflammation. C-fibers reduction (C-lesion) had
anti-inflammatory effects. In deficit C-fibers rats, acute and chronic stress
had not stronger anti-inflammatory effect, but acute dexamethasone reduced the
anti-inflammatory effect of C-fibers reduction while in the same condition,
chronic dexamethasone induced stronger anti-inflammatory effect. The results
show C-fiber nerve produce and release the peripheral inflammatory mediators, "C-fibers
reduction" decreased the paw inflammation. Counter adaptation in C-lesion
animals may reduce the modulatory effects of dexamethasone on
the remaining C-fibers. Acute dexamethasone diminished the "C-fibers
reduction" anti-inflammatory effect, but at
chronic treatment, the modulatory effects of dexamethasone aggregated and it
augmented the C-fibers reduction anti-inflammatory effect. |
| Page(s): | 633-637 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(09) [September 2012]
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