Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14596
Title: <span style="font-size:11.0pt;mso-bidi-font-size:10.0pt; font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:AR-SA">Antidepressant and anxiolytic-like effects of<span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:AR-SA" lang="EN-GB"> 4n, a novel 5-HT<sub>3</sub> receptor antagonist using behaviour based rodent models</span></span>
Authors: Kumar, Baldev
Jindal, Ankur
Pandey, Dilip Kumar
Bhatt, Shvetank
Keywords: <span style="font-size:9.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">5-HT<sub>3</sub> receptor antagonist</span>
Depression
Forced swim test
Light-dark aversion test
N-n-butylquinoxalin-2-carboxamide
Olfactory bulbectomy
Issue Date: Sep-2012
Publisher: NISCAIR-CSIR, India
Abstract: The present study was designed<i style="mso-bidi-font-style:normal"> </i>to investigate the<span style="mso-ansi-language:EN-IN;mso-fareast-language:EN-IN"> putative <span style="mso-ansi-language:EN-IN;mso-fareast-language:EN-IN">antidepressant and anxiolytic-like effects of <i><span style="mso-bidi-font-weight: bold">N</span></i><span style="mso-bidi-font-weight:bold">-n-Butylquinoxalin-2-carboxamide <b>(</b><b style="mso-bidi-font-weight:normal">4n),</b> a<span style="mso-ansi-language:EN-IN;mso-fareast-language:EN-IN"> novel 5-HT<sub>3</sub> receptor antagonist, with an optimal log P (2.01) and p<i style="mso-bidi-font-style: normal">A</i><sub>2</sub> value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depression and anxiety. Acute treatment of <b style="mso-bidi-font-weight:normal">4n</b> (1-4 mg/kg, ip) in mice produced antidepressant-like effect in forced swim test (FST) without affecting the baseline locomotion in actophotometer test in mice. <b style="mso-bidi-font-weight:normal">4n</b> (2-4 mg/kg, ip) treatment also potentiated the 5-hydroxytryptophan (5-HTP) induced head twitch response in mice. Further, <b style="mso-bidi-font-weight:normal">4n</b> (1-4 mg/kg, ip) treatment antagonized reserpine induced hypothermia in rats. Chronic treatment (14 days) with <b style="mso-bidi-font-weight:normal">4n</b> (1-4 mg/kg) and paroxetine (10 mg/kg) significantly attenuated the behavioural anomalies induced by bilateral olfactory bulbectomy in rats in modified open field <span style="mso-ansi-language:EN-IN;mso-fareast-language:EN-IN">paradigm. <span style="mso-ansi-language:EN-IN;mso-fareast-language: EN-IN">An anxiogenic-like behaviour was induced by light alone as the stimulus using light-dark aversion test. <b style="mso-bidi-font-weight:normal">4n</b> (2-4 mg/kg, ip) treatment significantly increased no. of transitions between dark and lit area and the time spent in the lit area. In conclusion, these preliminary investigations confirm that <b style="mso-bidi-font-weight: normal">4n</b> exhibited antidepressant and <span style="mso-ansi-language: EN-IN;mso-fareast-language:EN-IN">anxiolytic-like effects in rodent models of depression and anxiety. </span></span></span></span></span></span></span>
Description: 625-632
URI: http://hdl.handle.net/123456789/14596
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(09) [September 2012]

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