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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(09) [September 2012] >
| Title: | Regulation of telomerase activity in ovarian granulosa cells |
| Authors: | Chronowska, Ewa |
| Keywords: | Differentiation
Follicle
Granulosa cells
Ovary
Proliferation
Telomerase |
| Issue Date: | Sep-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Follicular
development is characterized by intensive proliferation and differentiation of
granulosa cells. It was reported that during follicular growth granulosa cells
arise from the population of stem cells. One of the main evidences for stem
characteristics of the cell is the ability to express telomerase – an enzyme
complex responsible for integrity and stability of chromosome ends (telomeres).
It was demonstrated that telomerase activity in granulosa cells is linked to
their proliferation and differentiation status and is under the control of growth
factors and steroid hormones. In this review current knowledge on the existence
and regulation of telomerase activity in granulosa cells has been presented.
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| Page(s): | 595-601 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(09) [September 2012]
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