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Title: Antibacterial effect of squid ink on ESBL producing strains of Escherichia coli and Klebsiella pneumoniae.
Authors: Smiline, Girija A.S
Vijayshree, Priyadharshini J
Pandi, Suba K
Hariprasad, P
Raguraman, R
Keywords: ESBL
Squid ink
Antibacterial activity
Issue Date: Aug-2012
Publisher: NISCAIR-CSIR, India
Abstract: Present study consist a novel therapeutics from natural sources to prevent the emergence and proliferation of resistant microbial populations that can make a significant impact in treating clinically challenging microbial infections. Squid ink has proved to play various primary roles in the world of alternative medicine and has widest range of therapeutic applications. Present study is designed to report the antibacterial effect of the squid ink against the ESBL producing strains of E.coli and K.pneumoniae. ESBL strains are isolated from patients with typical urinary tract infections. They have been identified microbiologically and characterized by double disc synergy test and plasmid profiles. Active metabolite of squid ink was extracted using solvents and was checked for its antibacterial activity by agar well diffusion method. MIC value is determined by microbroth dilution method. Results conclude that the hexane extract of the squid ink scored high antibacterial activity against the ESBL producing strains of E.coli and K.pneumoniae. Present study suggests that squid ink is an enigmatic pigment of therapeutic value in near future for treatment of dreadful infections caused by the ESBL strains.
Page(s): 338-343
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Source:IJMS Vol.41(4) [August 2012]

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