Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14545
Title: <span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Effect of acute exposure of N, N-Dimethylformamide, an industrial solvent on lipid peroxidation and antioxidants in liver and kidney of rats</span>
Authors: Jyothi, Kanagaraj
Kalyani, Durai
Nachiappan, Vasanthi
Keywords: N, N-Dimethylformamide
Hepatotoxicity
Nephrotoxicity
Histopathology
Lipid peroxidation
Oxidative stress
Enzymatic antioxidants
Non-enzymatic antioxidants
Issue Date: Aug-2012
Publisher: NISCAIR-CSIR, India
Abstract: <span style="mso-bidi-font-weight: bold" lang="EN-GB">N, N-Dimethylformamide (DMF), an industrial solvent widely used throughout the world is a known toxic compound. Here, we studied the effects of acute exposure of DMF on liver and kidney in rats. Rats were treated <span style="mso-bidi-font-weight:bold">intraperitoneally with a single dose of DMF (1.5 g/kg) for 24 and 48 h. Hepatic and nephrotoxicity was confirmed based on the significant increase in the serum levels of aspartate amino transferase, alanine amino transferase, alkaline phosphatase, <span style="font-family:Symbol;mso-ascii-font-family:" times="" new="" roman";="" mso-hansi-font-family:"times="" roman";mso-char-type:symbol;mso-symbol-font-family:="" symbol"="" lang="EN-GB">g-glutamyl transferase<span style="mso-bidi-font-weight:bold">, urea, creatinine and electrolytes. Oxidative stress was assessed by determining the levels of <span style="mso-bidi-font-style:italic">lipid peroxidation<span style="mso-bidi-font-weight:bold"> (LPO) and antioxidants in liver and kidney. The LPO levels were elevated in both the tissues upon DMF exposure, whereas the activities of enzymatic antioxidants SOD, CAT and Gpx and non-enzymatic antioxidants (glutathione and vitamin C<span style="mso-bidi-font-weight:bold">) were declined. The hepatic- and nephrotoxicity was further confirmed by the increasing incidence of inflammation in the histopathological studies. The findings indicate that acute exposure of DMF results in oxidative stress, antioxidant deficiency, attenuating liver and kidney marker enzymes, resulting in tissue inflammation and damage. </span></span></span></span></span></span></span>
Description: 279-284
URI: http://hdl.handle.net/123456789/14545
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.49(4) [August 2012]

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