|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(4) [August 2012] >
| Title: | Effect of acute exposure of N, N-Dimethylformamide, an industrial solvent on lipid peroxidation and antioxidants in liver and kidney of rats |
| Authors: | Jyothi, Kanagaraj
Kalyani, Durai
Nachiappan, Vasanthi |
| Keywords: | N, N-Dimethylformamide
Hepatotoxicity
Nephrotoxicity
Histopathology
Lipid peroxidation
Oxidative stress
Enzymatic antioxidants
Non-enzymatic antioxidants |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | N, N-Dimethylformamide (DMF), an industrial
solvent widely used throughout the world is a known toxic compound. Here, we
studied the effects of acute exposure of DMF on liver and kidney in rats. Rats
were treated intraperitoneally with a
single dose of DMF (1.5 g/kg) for 24 and 48 h. Hepatic and nephrotoxicity was
confirmed based on the significant increase in the serum levels of aspartate
amino transferase, alanine amino transferase, alkaline phosphatase, g-glutamyl transferase, urea,
creatinine and electrolytes. Oxidative stress was assessed by determining the
levels of lipid peroxidation (LPO) and antioxidants in liver and kidney.
The LPO levels were elevated in both the tissues upon DMF exposure, whereas the
activities of enzymatic antioxidants SOD, CAT and Gpx and non-enzymatic
antioxidants (glutathione and vitamin C)
were declined. The hepatic- and nephrotoxicity was further confirmed by the increasing
incidence of inflammation in the histopathological studies. The findings
indicate that acute exposure of DMF results in oxidative stress, antioxidant
deficiency, attenuating liver and kidney marker enzymes, resulting in tissue
inflammation and damage.
|
| Page(s): | 279-284 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(4) [August 2012]
|
|
