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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.15 [2008] >
IJCT Vol.15(3) [May 2008] >
| Title: | Clean and efficient synthesis of coumarins over modified metal oxides via Pechmann reaction |
| Authors: | D’Souza, Joyce
Nagaraju, N |
| Keywords: | Pechmann reaction
Coumarins
Solid acids
Metal oxides
Sulphate-modified zirconia
Borate-modified zirconia
Phosphate-modified zirconia
Alumina
Silica |
| Issue Date: | May-2008 |
| Publisher: | CSIR |
| Abstract: | The catalytic activity of solid acids such as zirconia, alumina and silica and their SO₄²⁻,PO₄³⁻ and BO₃³⁻ modified forms has been studied in the Pechmann reaction between resorcinol and ethylacetoacetate under solvent-free liquid phase reflux conditions and autogenous pressure.A systematic study of this reaction has been made by varying the following parameters: catalyst, amount of catalyst, duration and temperature of reaction and molar ratio of reactants. Under refluxing conditions, in the presence of sulphated zirconia, the percentage yield of the product, 7-hydroxy 4-methyl coumarin was in the range of 30-75% which, however, contained many impurities. When the same reaction was conducted in an autoclave at 150ºC, the clean product of yields upto 99% was obtained. Other phenols used in this work include catechol, hydroquinone, m-cresol, p-cresol, o-cresol, pyrogallol, phloroglucinol, orcinol, m-aminophenol and phenol.The sites of higher acid strength and perhaps super-acidic sites on the catalyst appear to be catalyzing the formation of coumarins via Pechmann reaction. Sulphated zirconia is found to be a promising catalyst for this reaction under autogenous conditions. |
| Page(s): | 244-251 |
| ISSN: | 0971–457X |
| Source: | IJCT Vol.15(3) [May 2008]
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