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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(4) [August 2012] >
| Title: | Role of PPARβ in fibroblast response to heat injury |
| Authors: | Zuo, Chenchen
Liang, Pengfei
Huang, Xiaoyuan |
| Keywords: | PPARβ
Fibroblast
Heat injury
In vitro wound healing model |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Peroxisome
proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor
family of ligand-inducible transcription factors. Our previous study has shown that in human umbilical vein
endothelial cells
PPARβ initiates a protective mechanism that limits the
extent of damage due to H2O2-induced injury. Although fibroblasts are
one of the main cell types involved in wound repair, the
role of PPARβ in the fibroblast response
to heat injury has not been investigated. Thus, in this
study, we examined possible protective role of PPARβ in fibroblasts from heat injury. We developed a novel dermal fibroblast heat
injury model to characterize the mechanisms of the heat injury healing response
that involved PPARβ. The specific PPARβ ligand GW0742, a PPARβ activator and a short hairpin
RNA (shRNA) plasmid against PPARβ were used to reveal the
action mechanism of PPARβ in heat injury-induced fibroblast changes in
morphology and increased proliferation. In response to heat
injury ( |
| Page(s): | 219-227 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(4) [August 2012]
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