|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.71 [2012] >
JSIR Vol.71(08) [August 2012] >
| Title: | Design of polypill for treatment of type -II diabetes mellitus associated with dyslipidemia |
| Authors: | Deshpande, Rohan D
Gowda, D.V.
Vasanti, S
Mahammed, Nawaz |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | This
study presents development of a bilayered tablet with sustained release (SR) of
Metformin hydrochloride (MH) and immediate release of Atorvastatin calcium
(AC), used as anti-hyperglycemic agent in patients with type 2 diabetes, by
lowering
both
basal and postprandial plasma glucose and competitive inhibitor of HMG-CoA
reductase. In SR layer, sodium carboxy methyl cellulose (Sodium CMC) and
Hydroxy Propyl Methylcellulose K4M (HPMC K4M) were used as retarding material
but
Hydroxy
Propyl Methylcellulose 15 Cps (HPMC 15 Cps) was used as channeling agent.
Tablets were prepared by wet granulation method. FT-IR studies showed no
interaction between drugs and polymers used in the study. Optimized formulation
gave
an initial burst effect and followed by SR for 8 h (92.53%), without any drug
degradation during stability studies. Drug release from formulation was dose
dependent and by diffusion mechanism. |
| Page(s): | 556-561 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.71(08) [August 2012]
|
|
