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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(08) [August 2012] >
| Title: | Ultrasound and microwave assisted rapid and sustainable route to synthesis of benzothiazine derivatives |
| Authors: | Dabholkar, Vijay V
avande, Rahul P G |
| Keywords: | 2-Aminobenzenethiol
1,4-benzothiazine
Ultra¬sound
MWI |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Ultrasound and microwave assisted synthesis
of 2-Meldrum-2H,4H-2-carbonyl methyl-3-oxo-1,4-benzothiazine 10, 2-dimi-done-2H,4H-2-carbonyl
methyl-3-oxo-1,4-benzothiazine 11, 2H,4H-2-amino-[3-methyl
pyrazol-5-one-1-yl]-carbonyl methyl-3-oxo-1,4-benzothiazine 12,2H,4H-2-amino-[3,5-dmethyl
pyrazol-1-yl]-carbonyl methyl-3-oxo-1,4-benzothiazine 13 and 2H, 4H-2-amino-[3-phenyl,
5-methyl pyrazol-1-yl]-carbonyl methyl-3-oxo-1,4-benzothiazine 14 from 2-aminobenzenethiol
and 1,3 diketo compounds containing active methylene group have been carried
out. All the synthesized compounds have been investigated for their
antibacterial activities. The result indicate that the compounds show convincing
activities against Gram-positive bacteria (Bacillus
subtilis and Streptococcus lactis)
when compared with standard drug (ampicillin trihydrate). These compounds have
been also synthesized by conventional method and their structures have been
elucidated on the basis of spectral analyses and chemical reactions. |
| Page(s): | 1173-1179 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(08) [August 2012]
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