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|Title:||Zinc chloride promoted efficient and facile BOC protection of amines|
Shinde, D B
|Keywords:||Amine protection;N-BOC protected amine;ZnCl2;Lewis acid|
|Abstract:||Amines are efficiently protected as their BOC derivatives under mild reaction conditions when reacted with BOC anhydride in presence of ZnCl2. The present method is applicable to a variety of amines including aliphatic, aromatic as well as heteroaromatic amines. This protocol appears to be competitive and in some cases superior to previously reported procedures that work under basic conditions.|
|Appears in Collections:||IJC-B Vol.51B(08) [August 2012]|
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