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Title: Design, microwave-assisted synthesis and in silico docking studies of new 4H-pyrimido[2,1-b]benzothiazole-2-arylamino-3-cyano-4-ones as possible adenosine A2B receptor antagonists
Authors: Balakumar, C
Kishore, D Pran
Rao, K Venkat
Narayana, B Lakshmi
Rajwinder, K
Rajkumar, V
Rao, A Raghuram
Keywords: <span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">4<i style="mso-bidi-font-style: normal">H</i>-pyrimido[2,1-<i style="mso-bidi-font-style:normal">b</i>]benzothiazole-4-one</span>
Adenosine receptor antagonists
docking studies
Microwave-assisted organic synthesis
Issue Date: Aug-2012
Publisher: NISCAIR-CSIR, India
Abstract: A series of new 4<i style="mso-bidi-font-style:normal">H</i>-pyrimido[2,1-<i style="mso-bidi-font-style: normal">b</i>]benzothiazole-2-arylamino-3-cyano-4-ones <b style="mso-bidi-font-weight: normal">6a-g</b> have been designed and synthesized by the application of microwave-assisted organic synthesis (MAOS) technique. <i style="mso-bidi-font-style: normal">I<span style="mso-bidi-font-style:italic">n silico </span></i><span style="mso-bidi-font-style:italic">docking studies have been carried out to gain an insight into the hypothetical binding motif of the title compounds using a homology model of A<sub>2B</sub> adenosine receptor employing GOLD (CCDC, 4.0.1 version) software. The binding modes are proposed on the basis of molecular docking studies. </span>
Description: 1105-1113
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(08) [August 2012]

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