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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(08) [August 2012] >
| Title: | Wound healing activity of methanolic and aqueous extracts of Plagiochila beddomei Steph. thallus in rat model |
| Authors: | Manoj, G S
Murugan, K |
| Keywords: | Angiogenic
Excision wound
Incision wound
Plagiochila beddomei
Secondary metabolites
Wound healing |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Wound
healing occurs as a fundamental response to tissue injury. Polyphenols are considered to be principle constituent to
promote wound healing. Plagiochila beddomei was applied clinically
by Paliyar tribes of Madurai
district to treat intractable wounds. To validate the ethnotherapeutic claims of the
plant in skin diseases, the effect of methanolic and aqueous extracts from P. beddomei on wound healing as
well as angiogenesis was studied. 7th day and 10th day after excision wounds creation, the
percent wound contraction of the extracts group was higher than that of
Madecassol® (reference drug) group.
On 3rd, 7th and 10th day after wounds
creation, the wound healing quality of the extracts group was better than that
of Madecassol® group on terms of
granulation formation and collagen organization. On 3rd day after
wounds creation, the micro vessel density and vascular endothelial growth
factor expression of methanolic extracts group was higher than that of
Madecassol® group. Phytochemical
analysis of the extracts showed the presence of flavonoids, saponins, tannins
and phenols. The results show that P. beddomei extract has potent wound healing property probably resulting from the
remarkable angiogenic activity. |
| Page(s): | 551-558 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(08) [August 2012]
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