Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14485
Title: <span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Wound healing activity <span style="mso-bidi-font-weight:bold">of methanolic and aqueous extracts of <i style="mso-bidi-font-style:normal">Plagiochila beddomei</i> Steph<i style="mso-bidi-font-style:normal">.</i> thallus in rat model</span></span>
Authors: Manoj, G S
Murugan, K
Keywords: Angiogenic
Excision wound
Incision wound
<i style="mso-bidi-font-style:normal"><span style="font-size:9.0pt;font-family:"Times New Roman";mso-fareast-font-family: "Times New Roman";mso-bidi-font-family:Mangal;mso-ansi-language:EN-GB; mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">Plagiochila beddomei</span></i>
Secondary metabolites
Wound healing
Issue Date: Aug-2012
Publisher: NISCAIR-CSIR, India
Abstract: <span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-bidi-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi;font-weight:normal;mso-bidi-font-weight:bold"="" lang="EN-GB">Wound healing occurs as a fundamental response to tissue injury. Polyphenols<b style="mso-bidi-font-weight:normal"><span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-bidi-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB"> </span></b><span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";="" mso-bidi-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:hi"="" lang="EN-GB">are considered to be principle constituent to promote wound healing.  <i><span style="font-size:11.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-bidi-font-family:mangal;mso-ansi-language:en-gb;="" mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB">Plagiochila beddomei</span></i><span style="font-size:9.0pt;mso-fareast-font-family: " times="" new="" roman";mso-bidi-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB"> was applied clinically by Paliyar tribes of Madurai district to treat intractable wounds.  <span style="font-size:11.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" times-roman;mso-bidi-font-family:mangal;mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:hi"="" lang="EN-GB">To validate the ethnotherapeutic claims of the plant in skin diseases, <span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-bidi-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB">the effect of methanolic and aqueous extracts from <i><span style="font-size:11.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-bidi-font-family:mangal;mso-ansi-language:en-gb;="" mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB">P. beddomei</span></i><span style="font-size:9.0pt;mso-fareast-font-family: " times="" new="" roman";mso-bidi-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB"> on wound healing as well as angiogenesis <span style="font-size:11.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:times-roman;mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">was studied.<span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-bidi-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB"> 7<sup>th</sup> day and 10<sup>th</sup> day after excision wounds creation, the percent wound contraction of the extracts group was higher than that of Madecassol<sup><span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB">®</span></sup><span style="font-size:9.0pt;mso-fareast-font-family: " times="" new="" roman";mso-bidi-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB"> (reference drug) group. On 3<sup>rd</sup>, 7<sup>th</sup> and 10<sup>th</sup> day after wounds creation, the wound healing quality of the extracts group was better than that of Madecassol<sup><span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB">®</span></sup><span style="font-size:9.0pt;mso-fareast-font-family: " times="" new="" roman";mso-bidi-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB"> group on terms of granulation formation and collagen organization. On 3<sup>rd</sup> day after wounds creation, the micro vessel density and vascular endothelial growth factor expression of methanolic extracts group was higher than that of Madecassol<sup><span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB">®</span></sup><span style="font-size:9.0pt;mso-fareast-font-family: " times="" new="" roman";mso-bidi-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:hi"="" lang="EN-GB"> group. Phytochemical analysis of the extracts showed the presence of flavonoids, saponins, tannins and phenols. <span style="font-size:11.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:times-roman;mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">The results show that <i><span style="font-size:11.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB">P. beddomei</span></i><span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";="" mso-bidi-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:hi"="" lang="EN-GB"> <span style="font-size: 11.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:times-roman;="" mso-bidi-font-family:mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB">extract has potent <span style="font-size:9.0pt;mso-fareast-font-family:" times="" new="" roman";="" mso-bidi-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:hi"="" lang="EN-GB">wound healing property probably resulting from the remarkable angiogenic activity<span style="font-size: 11.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:times-roman;="" mso-bidi-font-family:mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB">.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span>
Description: 551-558
URI: http://hdl.handle.net/123456789/14485
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(08) [August 2012]

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