Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14484
Title: <span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Role of complement activation and antibody in the interaction between <i>Mycobacterium tuberculosis </i>and human macrophages</span>
Authors: Manivannan, S
Rao, V Narayan
Ramanathan, V D
Keywords: Complement
Immunoglobulin
<i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">M. tuberculosis</span></i>
Phagocytosis
Issue Date: Aug-2012
Publisher: NISCAIR-CSIR, India
Abstract: <i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">M<span style="mso-bidi-font-weight:bold; mso-bidi-font-style:italic">ycobacterium tuberculosis</span></span></i><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">-specific antibodies possess immunomodulatory effects during tuberculosis infection. Prior sensitization to environmental mycobacteria is known to suppress immune responses against BCG and <i style="mso-bidi-font-style:normal">M. tuberculosis</i>. Mycobacteria-induced antibodies can influence events such as complement activation and phagocytosis during infectious process. In the present study role of anti-<i>M. tuberculosis</i> IgG (anti-<i>M. tb</i> IgG) antibody during interaction between <i>M. tuberculosis</i> and human macrophages mediated through complement has been examined <i style="mso-bidi-font-style:normal">in vitro</i>.<span style="mso-bidi-font-style:italic"> Anti-<i style="mso-bidi-font-style: normal">M. tb</i><span style="mso-bidi-font-style:italic"> IgG antibody significantly enhanced complement activation by <i style="mso-bidi-font-style: normal">M. tuberculosis</i>. Phagocytosis of <i style="mso-bidi-font-style: normal">M. tuberculosis</i> by macrophages increased significantly in the presence of complement and/or antibody. Moreover, antibody enhanced phagocytosis in the presence of complement. Addition of antibody alone or in combination with complement also augmented intracellular viability of bacilli within macrophages. Results of this study showed that anti-mycobacterial antibody enhances complement activation and anti-<i>M. tb</i> IgG antibody probably modulates effects of complement during early stages of tuberculosis infection.</span></span></span>
Description: 542-550
URI: http://hdl.handle.net/123456789/14484
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(08) [August 2012]

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