|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(08) [August 2012] >
| Title: | Role of complement activation and antibody in the interaction between Mycobacterium tuberculosis and human macrophages |
| Authors: | Manivannan, S
Rao, V Narayan
Ramanathan, V D |
| Keywords: | Complement
Immunoglobulin
M. tuberculosis
Phagocytosis |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Mycobacterium tuberculosis-specific antibodies possess immunomodulatory
effects during tuberculosis infection. Prior sensitization to environmental
mycobacteria is known to suppress immune responses against BCG and M. tuberculosis. Mycobacteria-induced
antibodies can influence events such as complement activation and phagocytosis
during infectious process. In the present study role of anti-M. tuberculosis
IgG (anti-M. tb IgG) antibody during interaction between M.
tuberculosis and human macrophages mediated through complement has been
examined in vitro. Anti-M. tb IgG antibody
significantly enhanced complement activation by M. tuberculosis. Phagocytosis of M. tuberculosis by macrophages increased significantly in the
presence of complement and/or antibody. Moreover, antibody enhanced
phagocytosis in the presence of complement. Addition of antibody alone or in
combination with complement also augmented intracellular viability of bacilli
within macrophages. Results of this study showed that anti-mycobacterial
antibody enhances complement activation and anti-M. tb IgG antibody
probably modulates effects of complement
during early stages of tuberculosis infection. |
| Page(s): | 542-550 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(08) [August 2012]
|
|
