|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Pure & Applied Physics (IJPAP) >
IJPAP Vol.50 [2012] >
IJPAP Vol.50(08) [August 2012] >
| Title: | New gallium(III) complex-synthesis, spectral characterization and cytotoxicity |
| Authors: | Kostova, Irena
Stefanova, Tsvetanka |
| Keywords: | Coumarin-3-carboxylic acid
Gallium(III) complex
FTIR
FT Raman spectra
Cytotoxicity assay |
| Issue Date: | Aug-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | New Ga(III) complex
of coumarin-3-carboxylic acid (HCCA) was synthesized and its structure and
spectral properties were investigated by elemental analysis, FTIR, FT Raman and
NMR measurements. According to the experimental data, the complex formula was
suggested. Vibrational frequencies, IR intensities and Raman activities as well
as 1H NMR chemical shifts of HCCA and its Ga(III) complex are
presented. The comparative experimental vibrational and NMR analyses of both
the ligand and the Ga(III) complex predicted the bidentate binding to Ga(III)
through the deprotonated carboxylic oxygen and the carbonylic oxygen of the
ligand. The recorded spectra and the marker bands of characteristic functional
groups are identified, in order to use them as data bank for further
application in trace analysis of newly synthesized metal complexes. The
cytotoxic/cytostatic properties of the ligand and the newly synthesized complex
were tested by MTT reduction assay against two mouse tumor cell lines: melanoma
B16 and fibrosarcoma L929. They were also tested for cytotoxicity against
normal mouse peritoneal macrophages. The proliferation inhibitory effect of the
complex compared to that of the ligand proves its cytotoxic/cytostatic
properties against both the tumor cell lines. In addition, the complex is less
cytotoxic against normal mouse macrophages and is able to modulate NO release
by activated macrophages. The obtained results are in accordance with our
previously published data concerning the activity of lanthanide(III) complexes
with coumarin derivatives. |
| Page(s): | 547-554 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1041 (Online); 0019-5596 (Print) |
| Source: | IJPAP Vol.50(08) [August 2012]
|
|
