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Title: Synthesis and antimicrobial activity of 2-(2′-arylidene-hydrazino- acetyl-amino)-4-phenyl-1,3-thiazoles and 2-[2′-{4′′-substituted-aryl-3′′-chloro- 2′′-oxo-azetidine}-acetyl-amino]-4- phenyl-1,3-thiazoles
Authors: Sonwane, S K
Srivastava, S D
Srivastava, S K
Keywords: 2-Amino-4-phenyl-1,3-thiazole;Arylidenes;2-oxo-azetidines;Antimicrobial activity
Issue Date: Apr-2008
Publisher: CSIR
Abstract: As a part of systematic investigation of synthesis and biological activity, several new 2-(2′-substituted-arylidene-hydrazino- acetyl-amino)-4-phenyl-1,3-thiazoles, 3 and 2-[2′-{4′′-substituted-aryl-3′′- chloro-2′′-oxo-azetidine}-acetyl-amino]-4- phenyl-1,3-thiazoles, 4 have been synthesized from 2-(2′-hydrazino-acetyl)-amino-4- phenyl-1,3-thiazole, 2 using 2-amino-4-phenyl-1,3-thiazole as the starting material. All the synthesized products are evaluated for their antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride and antibacterial activity against Bacillus substilis, Eschericha coli. Klebsiella pneumoneae and Staphylococcus aureus respectively. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data.
Page(s): 633-636
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.47B(04) [April 2008]

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