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Title: <span style="font-size:15.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-US">Anti-inflammatory and antinociceptive activities of <i>Crotalaria burhia</i><span style="mso-bidi-font-style:italic"> Buch.-Ham. whole plant</span></span>
Authors: Kataria, Sandeep
Shrivastava, Birendra
Kaur, Dilsher
Sharma, Piush
Keywords: Acute toxicity
<i>Crotalaria burhia</i>
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Series/Report no.: Int. cl. (2011.01)-A61K 36/00, A61P 29/00
Abstract: <i>Crotalaria burhia </i><span style="mso-bidi-font-style:italic" lang="EN-GB">Buch.-Ham. <span style="mso-bidi-font-weight:bold">(Family-Fabaceae) popularly known as <i style="mso-bidi-font-style:normal"><span style="mso-bidi-font-weight: bold">Khip</span></i><span style="mso-bidi-font-weight:bold"> is employed in Indian folk medicine for the treatment of gout, hydrophobia, pain and swelling.<span style="mso-bidi-font-weight:bold"> In present study antinociceptive and anti-inflammatory activities were assessed using acetic-<span style="mso-bidi-font-weight:bold">acid induced writhing and formalin induced pain <span style="mso-bidi-font-weight:bold">in mice and acute, subacute models of inflammation in rats. <span style="mso-bidi-font-weight: bold">These studies demonstrated that <span style="mso-bidi-font-style: italic">oral administration of methanolic extract of whole plant (including aerial parts and root) of<i style="mso-bidi-font-style:normal"> C. burhia </i>(MECB) (100, 200, 400 mg/kg) exhibited significant antinociceptive and anti-inflammatory activities. In <span style="mso-bidi-font-style:italic">acetic acid writhing reflex model MECB 400 mg/kg, p.o. had shown significant antinociceptive effect but pretreatment with naloxone blocked the protective effect of the extract. In formalin induced pain MECB 400 mg/kg significantly inhibited the inflammation-induced pain better than the pain resulting from neurogenic phase. In acute inflammation as produced by carrageenan 62.19% after 6 h, by histamine 20.00%, by 5-hydroxytryptamine 27.27%, and by prostaglandin E<sub>2</sub> 26.92% protection was observed, while in subacute anti-inflammatory model using formaldehyde-induced hind paw edema (after 1.5 h) 49.29% protection from inflammation was observed at 400 mg/kg oral dose of MECB. MECB neither showed ulcerogenic effect at different doses of MECB nor any sign of toxicity and mortality up to a dose level of 5000 mg/kg, p.o. in rats and mice. These data indicate that MECB possesses significant antinociceptive and anti-inflammatory activities without ulcerogenic effect. </span></span></span></span></span></span></span></span></span>
Description: 189-196
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.3(2) [June 2012]

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