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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.3 [2012] >
IJNPR Vol.3(2) [June 2012] >
| Title: | Anti-inflammatory and antinociceptive activities of Crotalaria burhia Buch.-Ham. whole plant |
| Authors: | Kataria, Sandeep
Shrivastava, Birendra
Kaur, Dilsher
Sharma, Piush |
| Keywords: | Acute toxicity
Anti-inflammatory
Antinociceptive
Crotalaria burhia
Ulcerogenic |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2011.01)-A61K 36/00, A61P 29/00 |
| Abstract: | Crotalaria burhia Buch.-Ham. (Family-Fabaceae) popularly
known as Khip is employed
in Indian folk medicine for the treatment of gout, hydrophobia, pain and
swelling. In present study
antinociceptive and anti-inflammatory activities were assessed using acetic-acid induced writhing and formalin
induced pain in mice and acute,
subacute models of inflammation in rats. These studies demonstrated that oral administration of methanolic extract of whole plant
(including aerial parts and root) of C.
burhia (MECB) (100, 200, 400 mg/kg) exhibited significant antinociceptive and
anti-inflammatory activities.
In acetic acid writhing reflex
model MECB 400 mg/kg, p.o. had shown significant antinociceptive effect but
pretreatment with naloxone blocked the protective effect of the extract. In
formalin induced pain MECB 400 mg/kg significantly inhibited the
inflammation-induced pain better than the pain resulting from neurogenic phase.
In acute inflammation as produced by carrageenan 62.19% after 6 h, by histamine
20.00%, by 5-hydroxytryptamine 27.27%, and by prostaglandin E2
26.92% protection was observed, while in subacute anti-inflammatory model using
formaldehyde-induced hind paw edema
(after 1.5 h) 49.29% protection from inflammation was observed at 400 mg/kg
oral dose of MECB. MECB neither showed ulcerogenic effect at different doses of
MECB nor any sign of toxicity and mortality up to a dose level of 5000 mg/kg,
p.o. in rats and mice. These data indicate that MECB possesses significant
antinociceptive and anti-inflammatory activities without ulcerogenic effect.
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| Page(s): | 189-196 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.3(2) [June 2012]
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