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|Title:||Anti-inflammatory and antinociceptive activities of Crotalaria burhia Buch.-Ham. whole plant|
|Keywords:||Acute toxicity;Anti-inflammatory;Antinociceptive;Crotalaria burhia;Ulcerogenic|
|IPC Code:||Int. cl. (2011.01)-A61K 36/00, A61P 29/00|
|Abstract:||Crotalaria burhia Buch.-Ham. (Family-Fabaceae) popularly known as Khip is employed in Indian folk medicine for the treatment of gout, hydrophobia, pain and swelling. In present study antinociceptive and anti-inflammatory activities were assessed using acetic-acid induced writhing and formalin induced pain in mice and acute, subacute models of inflammation in rats. These studies demonstrated that oral administration of methanolic extract of whole plant (including aerial parts and root) of C. burhia (MECB) (100, 200, 400 mg/kg) exhibited significant antinociceptive and anti-inflammatory activities. In acetic acid writhing reflex model MECB 400 mg/kg, p.o. had shown significant antinociceptive effect but pretreatment with naloxone blocked the protective effect of the extract. In formalin induced pain MECB 400 mg/kg significantly inhibited the inflammation-induced pain better than the pain resulting from neurogenic phase. In acute inflammation as produced by carrageenan 62.19% after 6 h, by histamine 20.00%, by 5-hydroxytryptamine 27.27%, and by prostaglandin E2 26.92% protection was observed, while in subacute anti-inflammatory model using formaldehyde-induced hind paw edema (after 1.5 h) 49.29% protection from inflammation was observed at 400 mg/kg oral dose of MECB. MECB neither showed ulcerogenic effect at different doses of MECB nor any sign of toxicity and mortality up to a dose level of 5000 mg/kg, p.o. in rats and mice. These data indicate that MECB possesses significant antinociceptive and anti-inflammatory activities without ulcerogenic effect.|
|ISSN:||0976-0512 (Online); 0976-0504 (Print)|
|Appears in Collections:||IJNPR Vol.3(2) [June 2012]|
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