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|Title:||Phenolic profiles, antimicrobial and antioxidant potentiality of methanolic extract of a liverwort, Plagiochila beddomei Steph.|
|Authors:||Manoj, G S|
|IPC Code:||Int. cl. (2011.01)-A61K 36/10, A61P 31/00, A61P 39/06|
|Abstract:||The present study was carried out to evaluate antioxidant and antimicrobial activities of methanol extract of Plagiochila beddomei Steph. - a liverwort (Bryophyte). Total phenolics was fractionated by high performance liquid chromatography, showed the presence of a pool of phenolic acids such as coumaric, ferulic, gallic, caffeic, protocatechol, cinnamic, sinapate, chlorogenate and hydroxyl benzoate. Methanolic extract showed broad spectrum antimicrobial activity against various bacteria such as Salmonella typhimurium, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Bacillus cereus, B. subtilis, Proteus vulgaris, Pseudomonas aeruginosa and fungi like Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Aspergillus niger, A. flavus, A. terreus and Mucor indicus. Survivorship curve of bacteria and fungal spore germination were also analyzed. P.beddomei displayed significant antioxidant activity evaluated by 1,1-diphenyl- 2-picrylhydrazyl free radical-scavenging ability, ferric-reducing antioxidant power, ferric thiocyannate assay and hydroxyl radical-scavenging activity. Phenols and flavonoids were found to be present in high levels. Total phenol content was shown to provide the highest correlation with FRAP assay (R2 0.966). MTT assay revealed the non-toxic nature of the extract.|
|ISSN:||0976-0512 (Online); 0976-0504 (Print)|
|Appears in Collections:||IJNPR Vol.3(2) [June 2012]|
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