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Title: <span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Phenolic profiles, antimicrobial and antioxidant potentiality of methanolic extract of a liverwort,<i style="mso-bidi-font-style:normal"> Plagiochila beddomei</i> Steph.</span>
Authors: Manoj, G S
Murugan, K
Keywords: Antimicrobial
<i>Plagiochila beddomei</i>
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Series/Report no.: Int. cl. (2011.01)-A61K 36/10, A61P 31/00, A61P 39/06
Abstract: The present study was carried out to evaluate antioxidant and antimicrobial activities of methanol extract of <i style="mso-bidi-font-style:normal">Plagiochila beddomei </i>Steph<i style="mso-bidi-font-style:normal">.</i><span style="mso-bidi-font-style:italic"> - a liverwort (Bryophyte). Total phenolics was fractionated by high performance liquid chromatography, showed the presence of a pool of phenolic acids such as coumaric, ferulic, gallic, caffeic, protocatechol, cinnamic, sinapate, chlorogenate and hydroxyl benzoate. Methanolic extract showed broad spectrum antimicrobial activity against various bacteria such as <i style="mso-bidi-font-style:normal">Salmonella<span style="mso-bidi-font-style: italic"> typhimurium, Staphylococcus aureus</span></i>, <i style="mso-bidi-font-style: normal">Klebsiella pneumoniae, Escherichia coli</i>, Bacillus cereus, <i>B. subtilis</i><span style="mso-bidi-font-style:italic" lang="EN-GB">, <i style="mso-bidi-font-style:normal">Proteus vulgaris</i>, Pseudomonas aeruginosa and fungi like Candida albicans, <i style="mso-bidi-font-style: normal">Cryptococcus neoformans</i>, Trichophyton rubrum, Aspergillus niger, A. flavus, A. terreus and<i style="mso-bidi-font-style:normal"> Mucor indicus</i>. Survivorship curve of bacteria and fungal spore germination were also analyzed. <i style="mso-bidi-font-style:normal">P.beddomei </i>displayed significant antioxidant activity evaluated by 1,1-diphenyl- 2-picrylhydrazyl free radical-scavenging ability, ferric-reducing antioxidant power, ferric thiocyannate assay and hydroxyl radical-scavenging activity. Phenols and flavonoids were found to be present in high levels. Total phenol content was shown to provide the highest correlation with FRAP assay (R<sup>2</sup> 0.966). MTT assay revealed the non-toxic nature of the extract. </span></span>
Description: 173-183
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.3(2) [June 2012]

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