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IJNPR Vol.3(2) [June 2012] >
|Title: ||Phenolic profiles, antimicrobial and antioxidant potentiality of methanolic extract of a liverwort, Plagiochila beddomei Steph.|
|Authors: ||Manoj, G S|
|Issue Date: ||Jun-2012 |
|Publisher: ||NISCAIR-CSIR, India|
|IPC Code: ||Int. cl. (2011.01)-A61K 36/10, A61P 31/00, A61P 39/06|
|Abstract: ||The present study was carried out to
evaluate antioxidant and antimicrobial activities of methanol extract of Plagiochila beddomei Steph.
- a liverwort (Bryophyte). Total phenolics was fractionated by high
performance liquid chromatography, showed the presence of a pool of phenolic
acids such as coumaric, ferulic, gallic, caffeic, protocatechol, cinnamic,
sinapate, chlorogenate and hydroxyl benzoate. Methanolic extract showed broad
spectrum antimicrobial activity against various bacteria such as Salmonella typhimurium, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Bacillus cereus, B.
subtilis, Proteus vulgaris, Pseudomonas aeruginosa and fungi
like Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Aspergillus
niger, A. flavus, A. terreus
and Mucor indicus. Survivorship curve
of bacteria and fungal spore germination were also analyzed. P.beddomei displayed significant
antioxidant activity evaluated by 1,1-diphenyl- 2-picrylhydrazyl free
radical-scavenging ability, ferric-reducing antioxidant power, ferric
thiocyannate assay and hydroxyl radical-scavenging activity. Phenols and
flavonoids were found to be present in high levels. Total phenol content was
shown to provide the highest correlation with FRAP assay (R2 0.966).
MTT assay revealed the non-toxic nature of the extract.
|CC License: || CC Attribution-Noncommercial-No Derivative Works 2.5 India|
|ISSN: ||0976-0512 (Online); 0976-0504 (Print)|
|Source:||IJNPR Vol.3(2) [June 2012]|