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Title: Macro-microscopic evaluation and HPTLC-densitometric analysis of solasodine from fruits of some medicinally important species in genus Solanum Linn
Authors: Upadhye, A S
Kumbhalkar, B B
Deshpande, A S
Keywords: Authentication;Fruits;HPTLC;Solanum sp.;Solanaceae;Solasodine;Steroidal drugs.
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01)-A61K 36/81, A61K 131/00
Abstract: Fruits of Solanum Linn. (Family ¾ Solanaceae) species, viz. S. anguivi Lam., S. nigrum Linn., S. melongena Linn., S. virginianum Linn. and S. torvum Sw. are used in Indian traditional system of medicine for diverse pharmacological activities. These fruits are foremost source of solasodine which is one of the major starting materials used for commercial synthesis of steroidal drugs. In the present study, comparative micro-morphology of fruits of above five species and estimation of active principle solasodine with HPTLC-densitometric method has been carried out. An artificial key based on macroscopic and microscopic characters were developed for identification and authentication of fruits. The trend of solasodine content was as: S. virginianum > S. nigrum > S. torvum > S. anguivi > S. melongena. This data is helpful in identification and authentication of plant samples and quantification of the active marker solasodine.
Page(s): 166-172
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.3(2) [June 2012]

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