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IJC-B Vol.47B(04) [April 2008] >


Title: Conventional as well as microwave assisted synthesis of some new N⁹-[hydrazinoacetyl-(2-oxo-3-chloro-4-substituted aryl azetidine)]-carbazoles: Antifungal and antibacterial studies
Authors: Srivastava, S K
Nema, A
Srivastava, S D
Keywords: Azetidinones
Carbazoles
Conventional
Microwave assisted synthesis
Antifungal activity
Antibacterial activity
Issue Date: Apr-2008
Publisher: CSIR
Abstract: Carbazole on reaction with chloroacetyl chloride afford N⁹-(chloroacetyl)-carbazole, 1 which on treatment with hydrazine hydrate has yielded N⁹-(hydrazinoacetyl)-carbazole, 2. Condensation of 2 with various aromatic aldehydes afforded N⁹-(arylidene hydrazinoacetyl)-carbazoles, 3 which on cycloaddition with chloroacetyl chloride in the presence of triethylamine yielded N⁹-[hydrazinoacetyl-(2-oxo-3-chloro-4-substituted aryl azeitidine)]-carbazoles 4. All the above reactions are also performed by microwave assisted synthetic method. The structures of all the products are characterized by microanalytical data and spectroscopic techniques. All the synthesized products are screened for their antibacterial activity against Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and antifungal activity against Aspergillus nigar, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride.
Page(s): 606-612
ISSN: 0376-4699
Source:IJC-B Vol.47B(04) [April 2008]

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