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Title: Fuller’s earth catalyzed rapid synthesis of bis(indolyl)methanes under solvent free condition
Authors: Kapuriya, Naval
Kakadiya, Rajesh
Savant, Mahesh M
Pansuriya, Akshay M
Bhuva, Chirag V
Patel, Anil S
Pipaliya, Piyush V
Audichya, Vipul B
Gangadharaiah, Sarala
Anandalwar, Sridhar M
Prasad, Javaregowda S
Shah, Anamik
Naliapara, Yogesh T
Keywords: Fuller’s earth
Electrophilic addition
Water mediated
Solvent free condition
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: A rapid and highly efficient synthesis of various bis(indolyl)methanes with high yield by the reaction of indoles 1a-c and arylaldehydes 2a'-m' in presence of fuller’s earth is demonstrated. This simple and versatile protocol is found to be an efficient catalyst for the electrophilic addition reaction of indole and works well under solvent free condition as well as in aqueous medium. The structure of newly synthesized compound 3m has been confirmed by single crystal X-ray crystallography.
Description: 1032-1038
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(07) [July 2012]

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