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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(04) [April 2008] >
| Title: | QSAR studies on 4-thiazolidinones and 2-azetidinones bearing benzothiophene nucleus as potential anti-tubercular agents |
| Authors: | Narute, A S
Khedekar, P B
Bhusari, K P |
| Keywords: | Anti-tubercular activity
QSAR
Benzothiaphene
Anti-tubercular agents |
| Issue Date: | Apr-2008 |
| Publisher: | CSIR |
| Abstract: | Quantitative structure-activity relationships (QSAR) study on a series of (substituted 1, 2-dihydro)4–thiazolidinones and 2-azetidinones bearing benzothiophene nucleus with anti-tubercular activity has been carried out using a combination of various physicochemical descriptors. Several significant equations with good co-efficient of correlation (>0.860) have been obtained. The two models are selected using internal predictive power discerned by cross-validated coefficient q². Both models highlight some common important feature, i.e., bulky substitution and the high nucleophilicity nature of the molecules, favorable for anti-tubercular activity. |
| Page(s): | 586-591 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(04) [April 2008]
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