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IJC-B Vol.47B [2008] >
IJC-B Vol.47B(04) [April 2008] >


Title: QSAR studies on 4-thiazolidinones and 2-azetidinones bearing benzothiophene nucleus as potential anti-tubercular agents
Authors: Narute, A S
Khedekar, P B
Bhusari, K P
Keywords: Anti-tubercular activity
QSAR
Benzothiaphene
Anti-tubercular agents
Issue Date: Apr-2008
Publisher: CSIR
Abstract: Quantitative structure-activity relationships (QSAR) study on a series of (substituted 1, 2-dihydro)4–thiazolidinones and 2-azetidinones bearing benzothiophene nucleus with anti-tubercular activity has been carried out using a combination of various physicochemical descriptors. Several significant equations with good co-efficient of correlation (>0.860) have been obtained. The two models are selected using internal predictive power discerned by cross-validated coefficient q². Both models highlight some common important feature, i.e., bulky substitution and the high nucleophilicity nature of the molecules, favorable for anti-tubercular activity.
Page(s): 586-591
ISSN: 0376-4699
Source:IJC-B Vol.47B(04) [April 2008]

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