Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14358
Title: Synthesis, characterization and antimicrobial screening of some quinoline based dihydropyridine and 2-oxo-azetidine derivatives
Authors: Desai, N C
Harsora, J P
Keywords: Vilsmeier-Haack reaction
Quinoline
2-pyridone
Thiazole
Azetidinones
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: <span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">2-Chloro-8-methylquinoline-3-carbaldehyde <b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-US">1 </span></b><span style="font-size:12.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-US">on treatment with <span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">2-cyanoacetohydrazide<span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-US"> and thiosemicarbazide yields schiff bases <i><span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa;mso-bidi-font-weight:bold"="" lang="EN-GB">N'</span></i><span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa;mso-bidi-font-weight:bold"="" lang="EN-GB">-((2-chloroquinolin-3-yl)methylene)-2-cyanoacetohydrazide <b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-GB">2 </span></b><span style="font-size:12.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-US">and <span style="font-size:12.0pt;font-family:" times="" new="" roman";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-gb;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa;mso-bidi-font-weight:bold"="" lang="EN-GB">2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinecarbothioamide <b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-GB">4</span></b><span style="font-size:12.0pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">,<span style="mso-bidi-font-weight:bold"> respectively.<span style="font-size:12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-US"> Compounds <b style="mso-bidi-font-weight:normal">2 </b><span style="mso-bidi-font-weight:bold">and<b style="mso-bidi-font-weight: normal"> 4</b> have been used to obtain a series of titled compounds containing azetidinone, thiazole and 2-pyridone scaffolds incorporating quinoline nucleus. The newly synthesized compounds <b>3a-j</b> and <b style="mso-bidi-font-weight: normal">6a-g</b> have been screened for their antibacterial and antifungal activities and their chemical structures have been elucidated by spectral data.</span></span></span></span></span></span></span></span></span></span></span>
Description: 1011-1019
URI: http://hdl.handle.net/123456789/14358
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(07) [July 2012]

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