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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(07) [July 2012] >
| Title: | Synthesis, characterization and antimicrobial screening of some quinoline based dihydropyridine and 2-oxo-azetidine derivatives |
| Authors: | Desai, N C
Harsora, J P |
| Keywords: | Vilsmeier-Haack reaction
Quinoline
2-pyridone
Thiazole
Azetidinones |
| Issue Date: | Jul-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Chloro-8-methylquinoline-3-carbaldehyde
1 on
treatment with 2-cyanoacetohydrazide and thiosemicarbazide yields schiff bases N'-((2-chloroquinolin-3-yl)methylene)-2-cyanoacetohydrazide
2 and
2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinecarbothioamide
4, respectively. Compounds 2 and 4 have been used to obtain a series of titled compounds containing
azetidinone, thiazole and 2-pyridone scaffolds incorporating quinoline nucleus.
The newly synthesized compounds 3a-j and 6a-g have been screened for their antibacterial and antifungal
activities and their chemical structures have been elucidated by spectral data. |
| Page(s): | 1011-1019 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(07) [July 2012]
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