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IJC-B Vol.51B(07) [July 2012] >


Title: Synthesis, characterization and antimicrobial screening of some quinoline based dihydropyridine and 2-oxo-azetidine derivatives
Authors: Desai, N C
Harsora, J P
Keywords: Vilsmeier-Haack reaction
Quinoline
2-pyridone
Thiazole
Azetidinones
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: 2-Chloro-8-methylquinoline-3-carbaldehyde 1 on treatment with 2-cyanoacetohydrazide and thiosemicarbazide yields schiff bases N'-((2-chloroquinolin-3-yl)methylene)-2-cyanoacetohydrazide 2 and 2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinecarbothioamide 4, respectively. Compounds 2 and 4 have been used to obtain a series of titled compounds containing azetidinone, thiazole and 2-pyridone scaffolds incorporating quinoline nucleus. The newly synthesized compounds 3a-j and 6a-g have been screened for their antibacterial and antifungal activities and their chemical structures have been elucidated by spectral data.
Page(s): 1011-1019
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(07) [July 2012]

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